TLR4 signaling drives mesenchymal stromal cells (MSC) commitment to promote tumor microenvironment transformation in multiple myeloma

被引:0
|
作者
Giallongo, Cesarina [1 ]
Tibullo, Daniele [2 ]
Parrinello, Nunziatina [1 ]
Camiolo, Giuseppina [2 ]
Barbato, Alessandro [1 ]
Puglisi, Fabrizio [1 ]
Cambria, Daniela [1 ]
Romano, Alessandra [1 ]
Conticello, Concetta [3 ]
Palumbo, Giuseppe Alberto [4 ]
Di Raimondo, Francesco [5 ]
机构
[1] Univ Catania, Azienda Policlin OVE, Div Hematol, Catania, Italy
[2] Univ Catania, BIOMETEC, Dipartimento Sci Biomed & Biotecnol, Catania, Italy
[3] GIMEMA, Italian Multiple Myeloma Network, Rome, Italy
[4] Univ Catania, CHIRMED, Dipartimento Chirurg Gen & Specialita Medicochiru, Catania, Italy
[5] Univ Catania, Dept Hematol, Catania, Italy
来源
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2019年 / 19卷 / 10期
关键词
Immunosuppression; MSC; TLR4;
D O I
10.1016/j.clml.2019.09.147
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
FP-062
引用
收藏
页码:E90 / E91
页数:2
相关论文
共 50 条
  • [21] Inhibition of TLR4 Signaling Affects Mitochondrial Fitness Overcoming Bortezomib Resistance in Myeloma Plasma Cells
    Giallongo, Cesarina
    Tibullo, Daniele
    Camiolo, Giuseppina
    Puglisi, Fabrizio
    Cambria, Daniela
    Barbato, Alessandro
    Parrinello, Nunziatina Laura
    Romano, Alessandra
    Conticello, Concetta
    Amorini, Angela
    Volti, Giovanni Li
    Lazzarino, Giuseppe
    Palumbo, Giuseppe A.
    Di Raimondo, Francesco
    BLOOD, 2019, 134
  • [22] The Heme Oxygenase-1/Carbon Monoxide Pathway Activates TLR4 Signaling Promoting Bortezomib Resistance in Multiple Myeloma Cells
    Giallongo, Cesarina
    Scandura, Grazia
    Barbato, Alessandro
    Romano, Alessandra
    Puglisi, Fabrizio
    Cambria, Daniela
    La Spina, Enrico
    Musumeci, Giuseppe
    Di Rosa, Michelino
    Conticello, Concetta
    Volti, Giovanni Li
    Palumbo, Giuseppe A.
    Di Raimondo, Francesco
    Tibullo, Daniele
    BLOOD, 2020, 136
  • [23] Disregulated Osteogenesis By Mesenchymal Stromal Cells (MSC) After In Vivo Exposure To Multiple Myeloma: Studies In a Novel Humanized Mouse Model For Bone Remodelling In Myeloma
    Groen, Richard W. J.
    Noort, Willy A.
    Sigmans, Jessica
    van Stralen, Aniek
    Aalders, Linda
    Raymakers, Reinier
    Yuan, Huipin
    Mitsiades, Constantine S.
    Martens, Anton
    BLOOD, 2013, 122 (21)
  • [24] The participation of Multipotent Mesenchymal stem/stromal cells (MSC) in the tumor microenvironment: tumor-associated fibroblasts and potent anti-cancer cellular vehicles
    Spaeth, Erika
    Andreeff, Michael
    Marini, Frank
    HUMAN GENE THERAPY, 2011, 22 (06) : A6 - A7
  • [25] TLR4 Signaling in Stromal Cells Is Critical for the Initiation of Allergic Th2 Responses to Inhaled Antigen
    Tan, Anna M.
    Chen, Hui-Chen
    Pochard, Pierre
    Eisenbarth, Stephanie C.
    Herrick, Christina A.
    Bottomly, H. Kim
    JOURNAL OF IMMUNOLOGY, 2010, 184 (07): : 3535 - 3544
  • [26] IGFBP-6/SONIC HEDGEHOG/TLR4 SIGNALING AXIS DRIVES BONE MARROW FIBROTIC TRANSFORMATION IN PRIMARY MYELOFIBROSIS
    Longhitano, L.
    Tibullo, D.
    Vicario, N.
    Giallongo, C.
    La Spina, E.
    Romano, A.
    Lombardo, S.
    Moretti, M.
    Masia, F.
    Coda, A. R. D.
    Venuto, S.
    Fontana, P.
    Parenti, R.
    Volti, G. Li
    Di Rosa, M.
    Palumbo, G. A.
    Liso, A.
    HAEMATOLOGICA, 2022, 107 : 60 - 61
  • [27] Bone marrow mesenchymal stromal cells retain their tumor-educated phenotype after treatment of multiple myeloma
    Chubar, A.
    Semenova, N.
    Kostroma, I.
    Gritsaev, S.
    Bessmeltsev, S.
    Kotova, A.
    Ivolgin, D.
    Enukashvily, N.
    CYTOTHERAPY, 2020, 22 (05) : S76 - S76
  • [28] Priming TLR3 and TLR4 in human adipose- and olfactory mucosa-derived mesenchymal stromal cells and comparison of their cytokine secretions
    Mohammad Jafari
    Alimohamad Asghari
    Ali-Akbar Delbandi
    Maryam Jalessi
    Mir Hadi Jazayeri
    Reza Samarei
    Nader Tajik
    Cytotechnology, 2020, 72 : 57 - 68
  • [29] Priming TLR3 and TLR4 in human adipose- and olfactory mucosa-derived mesenchymal stromal cells and comparison of their cytokine secretions
    Jafari, Mohammad
    Asghari, Alimohamad
    Delbandi, Ali-Akbar
    Jalessi, Maryam
    Jazayeri, Mir Hadi
    Samarei, Reza
    Tajik, Nader
    CYTOTECHNOLOGY, 2020, 72 (01) : 57 - 68
  • [30] HUMAN LIVER CARCINOMAS RECRUIT MESENCHYMAL STEM/STROMAL CELLS THAT CAN PROMOTE TUMOR GROWTH VIA PARACRINE SIGNALING
    Hernanda, P.
    Pedroza-Gonzales, A.
    van der Laan, L. J. W.
    Janssen, H. L. A.
    Peppelenbosch, M. P.
    Pan, Q.
    JOURNAL OF HEPATOLOGY, 2013, 58 : S431 - S431