Characterization of a novel TPMT mutation associated with azathioprine-induced myelosuppression

被引:7
作者
de Beaumais, Tiphaine Adam [1 ]
Fakhoury, May [1 ]
Pigneur, Benedicte [2 ]
Viola, Sheila [2 ]
Medard, Yves [1 ]
Broly, Franck [3 ]
Jacqz-Aigrain, Evelyne [1 ]
机构
[1] Robert Debre Hosp, Dept Paediat Pharmacol & Pharmacogenet, F-75935 Paris 19, France
[2] Trousseau Hosp, Dept Paediat Gastroenterol & Nutr, Paris, France
[3] Calmette Hosp, CHRU Lille, Biol & Pathol Ctr, UF Genopathy Pharmacotoxicogenet & Glycobiol, Lille, France
关键词
THIOPURINE S-METHYLTRANSFERASE; THERAPY; PHARMACOGENOMICS; DISEASE;
D O I
10.1111/j.1365-2125.2009.03439.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:770 / 772
页数:3
相关论文
共 4 条
[1]   Acute lymphoblastic leukaemia: a model for the pharmacogenomics of cancer therapy [J].
Cheok, MH ;
Evans, WE .
NATURE REVIEWS CANCER, 2006, 6 (02) :117-129
[2]   Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy [J].
Colombel, JF ;
Ferrari, N ;
Debuysere, H ;
Marteau, P ;
Gendre, JP ;
Bonaz, B ;
Soulé, JC ;
Modgliani, R ;
Touze, Y ;
Catala, P ;
Libersa, C ;
Broly, F .
GASTROENTEROLOGY, 2000, 118 (06) :1025-1030
[3]   Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease [J].
Dubinsky, MC ;
Lamothe, S ;
Yang, HY ;
Targan, SR ;
Sinnett, D ;
Théorêt, Y ;
Seidman, EG .
GASTROENTEROLOGY, 2000, 118 (04) :705-713
[4]   Characterisation of novel defective thiopurine S-methyltransferase allelic variants [J].
Garat, A. ;
Cauffiez, C. ;
Renault, N. ;
Lo-Guidice, J. M. ;
Allorge, D. ;
Chevalier, D. ;
Houdret, N. ;
Chavatte, P. ;
Loriot, M. A. ;
Gala, J. L. ;
Broly, F. .
BIOCHEMICAL PHARMACOLOGY, 2008, 76 (03) :404-415