Synthesis of the pyrrolidinone core of KSM-2690 B

被引：45

作者：

Donohoe, Timothy J. ^{[1
]}

Chiu, Jessica Y. K. ^{[1
]}

Thomas, Rhian E. ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 03期

关键词：

D O I：

10.1021/ol062705x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of the pyrrolidinone core of the polyene beta-lactone antibiotic KSM-2690 B is described. An ammonia-free Birch reductive aldol reaction utilizing acetaldehyde is one of the key steps, together with a ruthenium-catalyzed alkene isomerization reaction.

引用

页码：421 / 424

页数：4

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