Plasma cerebellin levels in patients with central serous chorioretinopathy

Purpose. - To evaluate levels of plasma cerebellin, cortisol, adrenaline and noradrenaline in patients with central serous chorioretinopathy (CSC). Materials and Methods. - This prospective study included 30 patients diagnosed with acute CSC (Group 1) and a control group of 30 age-matched, healthy subjects without CSC (Group 2). Levels of plasma cerebellin, cortisol, adrenaline and noradrenaline were examined in blood samples taken after 8-12 hours of fasting. A value of p < 0.05 was considered statistically significant in the comparative analyses. Results. - The mean plasma cerebellin level was found to be 232.56 +/- 113.28 pg/ml in Group 1 and 174.07 +/- 82.04 pg/ml in Group 2 (p = 0.02). Mean plasma cortisol was 13.19 +/- 3.87 mu g/ml in Group 1 and 9.55 +/- 2.92 mu g/ml in Group 2 (p < 0.01). Mean plasma adrenaline was 60.62 +/- 26.67 pg/ml in Group 1 and 46.17 +/- 19.20 pg/ml in Group 2 (p = 0.03). Mean plasma noradrenaline was 206.66 +/- 73.90 pg/ml in Group 1 and 149.96 +/- 51.36 pg/ml in Group 2 (p < 0.01). Conclusion. - It can be concluded that increased cerebellin may have a role in the etiology of CSC by increasing catecholamine expression from the adrenal medulla and indirectly by increasing cortisol levels via a paracrine effect from the adrenal cortex. (C) 2020 Elsevier Masson SAS. All rights reserved.