Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic rats

被引：18

作者：

Pinheiro, Marcelo S. ^{[1
]}

Rodrigues, Luhara S. ^{[1
]}

Neto, Leila S. ^{[1
]}

Moraes-Souza, Rafaianne Q. ^{[1
]}

Soares, Thaigra S. ^{[1
]}

Americo, Madileine F. ^{[1
]}

Campos, Kleber E. ^{[1
]}

Damasceno, Debora C. ^{[2
]}

Volpato, Gustavo T. ^{[1
,2
]}

机构：

[1] Univ Fed Mato Grosso UFMT, Lab Fisiol Sistemas & Toxicol Reprod, Inst Ciencias Biol & Saude, Av Valdon Varjao 6390, BR-78600000 Barra Do Garcas, MT, Brazil

[2] Univ Estadual Paulista, UNESP, Lab Pesquisa Expt Ginecol & Obstet, Fac Med Botucatu, Distrito Rubiao Jr S-N, BR-18618970 Botucatu, SP, Brazil

来源：

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2017年 / 89卷 / 01期

关键词：

Bauhinia holophylla; diabetes; lipid profile; medicinal plants; rats; AQUEOUS EXTRACT; ANTIDIABETIC ACTIVITY; FORFICATA; RISK;

D O I：

10.1590/0001-3765201720160050

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bauhinia holophylla, commonly known as "cow's hoof", is widely used in Brazilian folk medicine for the diabetes treatment. Therefore, the aim of this study was at evaluating the aqueous extract effect of Bauhinia holophylla leaves treatment on the streptozotocin-induced diabetic rats. Diabetes was induced by Streptozotocin (40 mg/Kg) in female Wistar rats. Oral administration of aqueous extract of Bauhinia holophylla leaves was given to non-diabetic and diabetic rats at a dose of 400 mg/kg during 21 days. On day 17 of treatment, the Oral Glucose Tolerance Test was performed to determine the area under the curve. At the end of the treatment, the animals were anesthetized and blood was collected for serum biochemical parameters analysis. After treatment with Bauhinia holophylla extract, non-diabetic and diabetic rats presented no glycemic changes. On the other hand, the plant treatment decreased body weight and increased ALT and AST activities. In conclusion, the treatment with aqueous extract of B. holophylla leaves given to diabetic rats presented no hypoglycemic effect in nondiabetic animals and no antidiabetic effect in diabetic animals with the doses studied. In addition, the diabetic animals treated with the B. holophylla extract showed inconvenient effects and its indiscriminate consumption requires particular carefulness.

引用

页码：263 / 272

页数：10

共 39 条

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