The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21)

被引：44
|
作者：
Strehl, S
Borkhardt, A
Slany, R
Fuchs, UE
König, M
Haas, OA
机构：
[1] St Anna Childrens Hosp, Childrens Canc Res Inst, A-1090 Vienna, Austria
[2] Univ Giessen, Dept Pediat Hematol & Oncol, D-35392 Giessen, Germany
[3] Univ Erlangen Nurnberg, Dept Genet, D-91058 Erlangen, Germany
来源：
ONCOGENE | 2003年 / 22卷 / 01期
关键词：
MLL gene; LASP1; gene; fusion transcript; t(11; 17)(q23; q21); retroviral transduction;
D O I：
10.1038/sj.onc.1206042
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The MLL gene at chromosome 11q23 is frequently rearranged in acute leukemia. Here we report the identification of a new MLL fusion partner in the case of an infant with AML-M4 and a t(11;17)(q23;q21) translocation. Fluorescence in situ hybridization (FISH) and RT-PCR analyses indicated a rearrangement of the MLL gene, but no fusion with previously identified MLL fusion partners at 17q, such as AF17 or MSF. Rapid amplification of cDNA ends (RACE) revealed an in-frame fusion of MLL to LASP1, a gene that is amplified and overexpressed in breast cancer. Retroviral transduction of myeloid progenitors demonstrated that MLL/LASP1 is the fourth known fusion of MLL with a cytoplasmic protein that has no in vitro transformation capability, thus establishing a potential subgroup among the MLL fusion proteins.
引用
收藏
页码：157 / 160
页数：4
相关论文
共 50 条
  • [41] High IGSF4 expression in pediatric M5 acute myeloid leukemia with t(9;11)(p22;q23)
    Kuipers, Jenny E.
    Coenen, Eva A.
    Balgobind, Brian V.
    Stary, Jan
    Baruchel, Andre
    de Haas, Valerie
    de Bont, Eveline S. J. M.
    Reinhardt, Dirk
    Kaspers, Gertjan J. L.
    Cloos, Jacqueline
    Danen-van Oorschot, Astrid A.
    den Boer, Monique L.
    Marschalek, Rolf
    Meyer, Claus
    Pieters, Rob
    Zwaan, C. Michel
    van den Heuvel-Eibrink, Marry M.
    BLOOD, 2011, 117 (03) : 928 - 935
  • [42] Pre-natal, clonal origin of t(1;11)(p32;q23) acute lymphoblastic leukemia in monozygotic twins
    Kotecha, Rishi S.
    Murch, Ashleigh
    Kees, Ursula
    Cole, Catherine H.
    LEUKEMIA RESEARCH, 2012, 36 (01) : 46 - 50
  • [43] Clinical and biological characteristics of adult de novo and secondary acute myeloid leukemia with balanced 11q23 chromosomal anomaly or MLL gene rearrangement compared to cases with unbalanced 11q23 anomaly:: confirmation of the existence of different entities with 11q23 breakpoint
    Archimbaud, E
    Charrin, C
    Magaud, JP
    Campos, L
    Thomas, X
    Fière, D
    Rimokh, R
    LEUKEMIA, 1998, 12 (01) : 25 - 33
  • [44] Clinical and biological characteristics of adult de novo and secondary acute myeloid leukemia with balanced 11q23 chromosomal anomaly or MLL gene rearrangement compared to cases with unbalanced 11q23 anomaly: confirmation of the existence of different entities with 11q23 breakpoint
    E Archimbaud
    C Charrin
    J-P Magaud
    L Campos
    X Thomas
    D Fière
    R Rimokh
    Leukemia, 1998, 12 : 25 - 33
  • [45] De novo acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): a clinicopathologic and cytogenetic study of an entity recently added to the WHO classification
    Sun, Jianlan
    Konoplev, Sergej N.
    Wang, Xuemei
    Cui, Wei
    Chen, Su S.
    Medeiros, L. Jeffrey
    Lin, Pei
    MODERN PATHOLOGY, 2011, 24 (03) : 384 - 389
  • [46] Phenotypic conversion from t(8;21) acute myeloid leukemia to MLL gene rearrangement-positive acute lymphoblastic leukemia
    Ohsaka, A
    Kato, K
    Hikiji, K
    HEMATOPATHOLOGY AND MOLECULAR HEMATOLOGY, 1998, 11 (3-4) : 185 - 192
  • [47] A new complex rearrangement in infant ALL:t(X;11;17)(p11.2;q23;q12)
    Brassesco, Maria Sol
    Valera, Elvis Terci
    Meyer, Claus
    Marschalek, Rolf
    Lopes, Bruno Almeida
    de Paula Queiroz, Rosane Gomes
    Calado, Rodrigo de Tocantins
    Scrideli, Carlos Alberto
    Tone, Luiz Gonzaga
    CANCER GENETICS, 2018, 228 : 110 - 114
  • [48] MLL tandem duplication in two cases of acute myelocytic leukemia with unbalanced translocations:: der(16)t(11;16)(q23;p13) and der(18)t(11;18)(q22;p11.2)
    Aventín, A
    La Starza, R
    Casas, S
    Nomdedéu, J
    de Llano, MPQ
    Cimino, G
    Lo Coco, F
    Sierra, J
    Mecucci, C
    CANCER GENETICS AND CYTOGENETICS, 2003, 142 (01) : 8 - 12
  • [49] Genome-wide genotyping of acute myeloid leukemia with translocation t(9;11)(p22;q23) reveals novel recurrent genomic alterations
    Kuehn, Michael W. M.
    Bullinger, Lars
    Groeschel, Stefan
    Kroenke, Jan
    Edelmann, Jennifer
    Ruecker, Frank G.
    Eiwen, Karina
    Paschka, Peter
    Gaidzik, Verena I.
    Holzmann, Karlheinz
    Schlenk, Richard F.
    Doehner, Hartmut
    Doehner, Konstanze
    HAEMATOLOGICA, 2014, 99 (08) : E133 - E135
  • [50] Stability and subcellular localization of API2-MALT1 chimeric protein involved in t(11;18) (q21;q21) MALT lymphoma
    Izumiyama, K
    Nakagawa, M
    Yonezumi, M
    Kasugai, Y
    Suzuki, R
    Suzuki, H
    Tsuzuki, S
    Hosokawa, Y
    Asaka, M
    Seto, M
    ONCOGENE, 2003, 22 (50) : 8085 - 8092
12345