The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21)

被引：44
|
作者：
Strehl, S
Borkhardt, A
Slany, R
Fuchs, UE
König, M
Haas, OA
机构：
[1] St Anna Childrens Hosp, Childrens Canc Res Inst, A-1090 Vienna, Austria
[2] Univ Giessen, Dept Pediat Hematol & Oncol, D-35392 Giessen, Germany
[3] Univ Erlangen Nurnberg, Dept Genet, D-91058 Erlangen, Germany
来源：
ONCOGENE | 2003年 / 22卷 / 01期
关键词：
MLL gene; LASP1; gene; fusion transcript; t(11; 17)(q23; q21); retroviral transduction;
D O I：
10.1038/sj.onc.1206042
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The MLL gene at chromosome 11q23 is frequently rearranged in acute leukemia. Here we report the identification of a new MLL fusion partner in the case of an infant with AML-M4 and a t(11;17)(q23;q21) translocation. Fluorescence in situ hybridization (FISH) and RT-PCR analyses indicated a rearrangement of the MLL gene, but no fusion with previously identified MLL fusion partners at 17q, such as AF17 or MSF. Rapid amplification of cDNA ends (RACE) revealed an in-frame fusion of MLL to LASP1, a gene that is amplified and overexpressed in breast cancer. Retroviral transduction of myeloid progenitors demonstrated that MLL/LASP1 is the fourth known fusion of MLL with a cytoplasmic protein that has no in vitro transformation capability, thus establishing a potential subgroup among the MLL fusion proteins.
引用
收藏
页码：157 / 160
页数：4
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