Congenital mesoblastic nephroma 50 years after its recognition: A narrative review

被引：73

作者：

Gooskens, S. L. ^{[1
,2
]}

Houwing, M. E. ^{[1
,2
]}

Vujanic, G. M. ^{[3
]}

Dome, J. S. ^{[4
]}

Diertens, T. ^{[1
]}

Coulomb-l'Hermine, A. ^{[5
]}

Godzinski, J. ^{[6
]}

Pritchard-Jones, K. ^{[7
]}

Graf, N. ^{[8
]}

van den Heuvel-Eibrink, M. M. ^{[1
]}

机构：

[1] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands

[2] Sophia Childrens Univ Hosp, Dept Pediat Oncol, Erasmus MC, Rotterdam, Netherlands

[3] Univ Hosp Wales Cardiff, Univ Sch Med, Dept Cellular Pathol, Heath Pk, Cardiff, S Glam, Wales

[4] Childrens Natl Hlth Syst, Div Oncol, Washington, DC USA

[5] Hop Univ Est Parisien, Dept Pathol, Trousseau La Roche Guyon, France

[6] Med Univ Wroclaw, Dept Emergency Med, Wroclaw, Poland

[7] UCL, Canc Sect, Inst Child Hlth, London, England

[8] Saarland Univ, Dept Pediat Hematol & Oncol, Saarbrucken, Germany

来源：

PEDIATRIC BLOOD & CANCER | 2017年 / 64卷 / 07期

基金：

欧盟第七框架计划;

关键词：

clinical characteristics; congenital mesoblastic nephroma; genetics; histology; infancy; outcome; renal tumor; review; treatment; SPINDLE-CELL TUMORS; RENAL TUMORS; FETAL HAMARTOMA; STROMAL TUMOR; ADULT; HYPERCALCEMIA; KIDNEY; POLYHYDRAMNIOS; RECURRENCE; EXPRESSION;

D O I：

10.1002/pbc.26437

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Congenital mesoblastic nephroma (CMN) is a rare pediatric renal tumor with low malignant potential that most commonly occurs early in infancy. Treatment strategies are based on the few published CMN series, while a significant number of CMN patients have been described in case reports. The aim of this narrative review was to create an up-to-date overview of the literature. Complete surgical removal is curative in most cases. The risk of treatment-related mortality (both surgery- and chemotherapy-related) is relatively high in the first weeks of life, indicating that these young patients deserve special attention with respect to timing and type of treatment.

引用

页数：9

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