Congenital mesoblastic nephroma 50 years after its recognition: A narrative review

被引:70
|
作者
Gooskens, S. L. [1 ,2 ]
Houwing, M. E. [1 ,2 ]
Vujanic, G. M. [3 ]
Dome, J. S. [4 ]
Diertens, T. [1 ]
Coulomb-l'Hermine, A. [5 ]
Godzinski, J. [6 ]
Pritchard-Jones, K. [7 ]
Graf, N. [8 ]
van den Heuvel-Eibrink, M. M. [1 ]
机构
[1] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands
[2] Sophia Childrens Univ Hosp, Dept Pediat Oncol, Erasmus MC, Rotterdam, Netherlands
[3] Univ Hosp Wales Cardiff, Univ Sch Med, Dept Cellular Pathol, Heath Pk, Cardiff, S Glam, Wales
[4] Childrens Natl Hlth Syst, Div Oncol, Washington, DC USA
[5] Hop Univ Est Parisien, Dept Pathol, Trousseau La Roche Guyon, France
[6] Med Univ Wroclaw, Dept Emergency Med, Wroclaw, Poland
[7] UCL, Canc Sect, Inst Child Hlth, London, England
[8] Saarland Univ, Dept Pediat Hematol & Oncol, Saarbrucken, Germany
基金
欧盟第七框架计划;
关键词
clinical characteristics; congenital mesoblastic nephroma; genetics; histology; infancy; outcome; renal tumor; review; treatment; SPINDLE-CELL TUMORS; RENAL TUMORS; FETAL HAMARTOMA; STROMAL TUMOR; ADULT; HYPERCALCEMIA; KIDNEY; POLYHYDRAMNIOS; RECURRENCE; EXPRESSION;
D O I
10.1002/pbc.26437
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Congenital mesoblastic nephroma (CMN) is a rare pediatric renal tumor with low malignant potential that most commonly occurs early in infancy. Treatment strategies are based on the few published CMN series, while a significant number of CMN patients have been described in case reports. The aim of this narrative review was to create an up-to-date overview of the literature. Complete surgical removal is curative in most cases. The risk of treatment-related mortality (both surgery- and chemotherapy-related) is relatively high in the first weeks of life, indicating that these young patients deserve special attention with respect to timing and type of treatment.
引用
收藏
页数:9
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