Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

被引：41

作者：

Yin, Yan ^{[1
,2
]}

Lin, Li ^{[1
,2
]}

Ruiz, Claudia ^{[1
,2
]}

Cameron, Michael D. ^{[1
,2
]}

Pocas, Jennifer ^{[1
,2
]}

Grant, Wayne ^{[1
,2
]}

Schroeter, Thomas ^{[1
,2
]}

Chen, Weimin ^{[1
,2
]}

Duckett, Derek ^{[1
,2
]}

Schuerer, Stephan ^{[3
,4
]}

LoGrasso, Philip ^{[1
,2
]}

Feng, Yangbo ^{[1
,2
]}

机构：

[1] Scripps Res Inst, Translat Res Inst, Jupiter, FL 33458 USA

[2] Scripps Res Inst, Dept Mol Therapeut, Jupiter, FL 33458 USA

[3] Univ Miami, Dept Pharmacol, Miami, FL 33136 USA

[4] Univ Miami, Ctr Computat Sci, Miami, FL 33136 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 23期

关键词：

ROCK; Rho; Benzothiazole; Chroman; Pyrazole; Glaucoma; INTRAOCULAR-PRESSURE; PROTEIN-KINASE; SMOOTH-MUSCLE; DESIGN; POTENT; HYPERTENSION; DISCOVERY; FASUDIL; TARGET; MODEL;

D O I：

10.1016/j.bmcl.2009.09.115

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of benzothiazole derivatives as ROCK inhibitors have been discovered. Compounds with good biochemical and cellular potency, and sufficient kinase selectivity have been identified. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6686 / 6690

页数：5

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