In vitro and in vivo antiplasmodial activity of cryptolepine and related alkaloids from Cryptolepis sanguinolenta

被引：219

作者：

Cimanga, K ^{[1
]}

DeBruyne, T ^{[1
]}

Pieters, L ^{[1
]}

Vlietinck, AJ ^{[1
]}

机构：

[1] UNIV MUNICH,INST PHARMAZEUT BIOL,D-80333 MUNICH,GERMANY

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 07期

关键词：

D O I：

10.1021/np9605246

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three different extracts and four alkaloids from the root bark of Cryptolepis sanguinolenta have been assessed in vitro against Plasmodium falciparum D-6 (chloroquine-sensitive strain), K-1, and W-2 (chloroquine-resistant strains). Cryptolepine (1) and its hydrochloride (2), 11-hydroxycryptolepine (3), and neocryptolepine (5) showed a strong antiplasmodial activity against P. falciparum chloroquine-resistant strains. Quindoline (4) was less active, The highest activity was obtained with compound 1. In vivo tests on infected mice showed that crytpolepine (1), when tested as hydrochloride (2), exhibited a significant chemosuppressive effect against Plasmodium berghei yoelii and Plasmodium berghei berghei, while 1 had the same effect against P. berghei yoelii only. Compounds 3 and 4 did not show activity in this in vivo test system.

引用

页码：688 / 691

页数：4

共 18 条

[1] A NEW ANTIMALARIAL QUASSINOID FROM SIMABA-GUIANENSIS [J].

CABRAL, JA ;

MCCHESNEY, JD ;

MILHOUS, WK .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (11) :1954-1961

[2] New alkaloids from Cryptolepis sanguinolenta [J].

Cimanga, K ;

DeBruyne, T ;

Pieters, L ;

Claeys, M ;

Vlietinck, A .

TETRAHEDRON LETTERS, 1996, 37 (10) :1703-1706

[3] In vitro biological activities of alkaloids from Cryptolepis sanguinolenta [J].

Cimanga, K ;

DeBruyne, T ;

Lasure, A ;

VanPoel, B ;

Pieters, L ;

Claeys, M ;

VandenBerghe, D ;

Kambu, K ;

Tona, L ;

Vlietinck, AJ .

PLANTA MEDICA, 1996, 62 (01) :22-27

[4] QUANTITATIVE ASSESSMENT OF ANTI-MALARIAL ACTIVITY INVITRO BY A SEMIAUTOMATED MICRODILUTION TECHNIQUE [J].

DESJARDINS, RE ;

CANFIELD, CJ ;

HAYNES, JD ;

CHULAY, JD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 16 (06) :710-718

[5] COMPARISON OF THE INVITRO ACTIVITIES OF QUASSINOIDS WITH ACTIVITY AGAINST PLASMODIUM-FALCIPARUM, ANISOMYCIN AND SOME OTHER INHIBITORS OF EUKARYOTIC PROTEIN-SYNTHESIS [J].

EKONG, RM ;

KIRBY, GC ;

PATEL, G ;

PHILLIPSON, JD ;

WARHURST, DC .

BIOCHEMICAL PHARMACOLOGY, 1990, 40 (02) :297-301

[6]

GUNATILAKA AAL, 1980, PLANTA MED, V39, P66

[7]

JACQUET C, 1994, TROP MED PARASITOL, V45, P267

[8] AKUAMMINE - AN ANTIMALARIAL INDOLEMONOTERPENE ALKALOID OF PICRALIMA-NITIDA SEEDS [J].

KAPADIA, GJ ;

ANGERHOFER, CK ;

ANSAASAMOAH, R .

PLANTA MEDICA, 1993, 59 (06) :565-566

[9] STUDIES ON INDONESIAN MEDICINAL-PLANTS .4. CYTOTOXIC AND ANTIMALARIAL CONSTITUENTS OF THE ROOTS OF EURYCOMA-LONGIFOLIA [J].

KARDONO, LBS ;

ANGERHOFER, CK ;

TSAURI, S ;

PADMAWINATA, K ;

PEZZUTO, JM ;

KINGHORN, AD .

JOURNAL OF NATURAL PRODUCTS, 1991, 54 (05) :1360-1367

[10]

Kerharo J., 1974, PHARM SENEGALAISE TR, P632

← 1 2 →