Templated Self-Assembly of a Covalent Polymer Network for Intracellular Protein Delivery and Traceless Release

被引：150
|
作者：
Dutta, Kingshuk [1 ]
Hu, Ding [1 ]
Zhao, Bo [1 ]
Ribbe, Alexander E. [2 ]
Zhuang, Jiaming [1 ]
Thayumanavan, S. [1 ,3 ,4 ]
机构：
[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
[2] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA
[3] Univ Massachusetts, Ctr Bioact Delivery, Inst Appl Life Sci, Amherst, MA 01003 USA
[4] Univ Massachusetts, Mol & Cellular Biol Program, Amherst, MA 01003 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 139卷 / 16期
关键词：
CYTOCHROME-C; BIOCONJUGATION; NANOPARTICLES; NANOCARRIERS; CONJUGATION; CHEMISTRY; PEPTIDES;
D O I：
10.1021/jacs.7b01214
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Trafficking proteins inside cells is an emerging field with potential utility in basic cell biology and biological therapeutics. A robust and sustainable delivery strategy demands not only good protection of the cargo but also reversibility in conjugation and activity. We report a protein-templated polymer self-assembly strategy for forming a sheath around the proteins and then tracelessly releasing them in the cytosol. The versatility of the approach, demonstrated here, suggests that the strategy is compatible with a wide array of biologics.
引用
收藏
页码：5676 / 5679
页数：4
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