THE EFFECT OF NEONICOTINOIDS ON MOUSE PREIMPLANTATION EMBRYO DEVELOPMENT IN VITRO

被引：0
作者：
Kubandova, Janka [1 ]
Sefcikova, Zuzana [1 ]
Kacmarova, Martina [1 ]
Burkus, Jan [1 ]
Cikos, Stefan [1 ]
Koppel, Juraj [1 ]
Fabian, Dusan [1 ]
机构：
[1] Slovak Acad Sci, Inst Anim Physiol, Kosice, Slovakia
来源：
ANIMAL PHYSIOLOGY 2016 | 2016年
关键词：
neonicotinoid; preimplantation embryo; toxicity; EXPOSURE; CLOTHIANIDIN; NICOTINE;
D O I：
暂无
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The aim of our preliminary study was to evaluate influence of neonicotinoids on physiological parameters of mouse preimplantation embryos. Neonicotinoids, which were developed in the 1990s, are a class of neuroactive insecticides chemically related to nicotine. Until recently, they were the most widely used insecticides, because they showed reduced toxicity compared to previously used organophosphate and carbamate insecticides according to their selective toxicity. We have analysed the influence of 4 neonicotinoids (Thiamethoxam, Clothianidin, Acetamiprid and Thiacloprid) at various concentrations (1 - 1000 mu M) on developmental and qualitative parameters of mouse preimplantation embryos cultured in vitro from 2-cells stage to the blastocysts stage. Our preliminary data indicated that the treatment of embryos with chemicals at concentration 1000 mu M during preimplantation period had negative effect on embryo developmental abilities in the case of all used neonicotinoids.
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页码：151 / 155
页数：5
相关论文
共 15 条
  • [1] Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort
    Berkowitz, GS
    Obel, J
    Deych, E
    Lapinski, R
    Godbold, J
    Liu, ZS
    Landrigan, PJ
    Wolff, MS
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2003, 111 (01) : 79 - 84
  • [2] Biogenic monoamines in preimplantation development
    Cikos, Stefan
    Fabian, Dusan
    Makarevich, Alexander V.
    Chrenek, Peter
    Koppel, Juraj
    [J]. HUMAN REPRODUCTION, 2011, 26 (09) : 2296 - 2305
  • [3] DeCant J., 2010, Environmental fate and ecological risk assessment for the registration of clothianidin for use as a seed treatment on mustard seed (oilseed and condiment) and cotton
  • [4] Reproductive Effects of Two Neonicotinoid Insecticides on Mouse Sperm Function and Early Embryonic Development In Vitro
    Gu, Yi-hua
    Li, Yan
    Huang, Xue-feng
    Zheng, Ju-fen
    Yang, Jun
    Diao, Hua
    Yuan, Yao
    Xu, Yan
    Liu, Miao
    Shi, Hui-juan
    Xu, Wen-ping
    [J]. PLOS ONE, 2013, 8 (07):
  • [5] The Effects of Di-(2-ethylhexyl)-phthalate Exposure on Fertilization and Embryonic Development In Vitro and Testicular Genomic Mutation In Vivo
    Huang, Xue-Feng
    Li, Yan
    Gu, Yi-Hua
    Liu, Miao
    Xu, Yan
    Yuan, Yao
    Sun, Fei
    Zhang, Hui-Qin
    Shi, Hui-Juan
    [J]. PLOS ONE, 2012, 7 (11):
  • [6] Huppertz Berthold, 2005, Birth Defects Research, V75, P249, DOI 10.1002/bdrc.20056
  • [7] Nicotine alters bovine oocyte meiosis and affects subsequent embryonic development
    Liu, Ying
    Li, Guang-Peng
    White, Kenneth L.
    Rickords, Lee F.
    Sessions, Benjamin R.
    Aston, Kenneth I.
    Bunch, Thomas D.
    [J]. MOLECULAR REPRODUCTION AND DEVELOPMENT, 2007, 74 (11) : 1473 - 1482
  • [8] Experimental exposure of red-legged partridges (Alectoris rufa) to seeds coated with imidacloprid, thiram and difenoconazole
    Lopez-Antia, Ana
    Ortiz-Santaliestra, Manuel E.
    Mougeot, Francois
    Mateo, Rafael
    [J]. ECOTOXICOLOGY, 2013, 22 (01) : 125 - 138
  • [9] Lorenzetti S. A. I., 2011, ANN I SUPER SANITA, V47, P16
  • [10] Marrs T. C., 2012, MAMMALIAN TOXIKOLOGY
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