The canine prostate cancer cell line CHP-1 shows over-expression of the co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein

被引：11

作者：

Azakami, D. ^{[1
]}

Nakahira, R. ^{[2
]}

Kato, Y. ^{[1
]}

Michishita, M. ^{[2
]}

Kobayashi, M. ^{[3
,4
]}

Onozawa, E. ^{[1
]}

Bonkobara, M. ^{[3
]}

Kobayashi, M. ^{[3
,4
]}

Takahashi, K. ^{[2
]}

Watanabe, M. ^{[5
]}

Ishioka, K. ^{[1
]}

Sako, T. ^{[1
]}

Ochiai, K. ^{[1
]}

Omi, T. ^{[1
]}

机构：

[1] Nippon Vet & Life Sci Univ, Sch Vet Nursing & Technol, Fac Vet Sci, Tokyo 1808602, Japan

[2] Nippon Vet & Life Sci Univ, Dept Vet Pathol, Fac Vet Sci, Tokyo, Japan

[3] Nippon Vet & Life Sci Univ, Dept Vet Clin Pathol, Fac Vet Sci, Tokyo, Japan

[4] Nippon Vet & Life Sci Univ, Dept Reprod, Fac Vet Sci, Tokyo, Japan

[5] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol, Okayama, Japan

来源：

VETERINARY AND COMPARATIVE ONCOLOGY | 2017年 / 15卷 / 02期

关键词：

androgen receptor signalling; canine; prostate cancer; small glutamine-rich tetratricopeptide repeat-containing protein; ANDROGEN RECEPTOR; SGTA; BINDING; DOMAIN;

D O I：

10.1111/vco.12199

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Although androgen therapy resistance and poor clinical outcomes are seen in most canine prostate cancer cases, there are only a few tools for analysing canine prostate cancer by using a cell biological approach. Therefore, to evaluate androgen-independent neoplastic cell growth, a new canine prostate cancer cell line (CHP-1) was established in this study. CHP-1 over-expressed the co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein (SGTA), which is over-expressed in human androgen-independent prostate cancer. The CHP-1 xenograft also showed SGTA over-expression. Although CHP-1 shows poor androgen receptor (AR) signalling upon dihydrotestosterone stimulation, forced expression of AR enabled evaluation of AR signalling. Taken together, these results suggest that CHP-1 will be a useful model for investigating the pathogenesis of androgen-dependent and androgen-independent canine prostate cancer.

引用

页码：557 / 562

页数：6

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