A Survival Score Based on Symptoms and Performance Status for Patients with High-grade Gliomas Receiving Radiochemotherapy

被引:2
作者
Pham Cam Phuong [1 ]
Le Viet Nam [1 ]
Schild, Steven E. [2 ]
Rades, Dirk [3 ,4 ]
Mai Trong Khoa [1 ,4 ]
机构
[1] Bach Mai Hosp, Nucl Med & Oncol Ctr, 78 Giai Phong St, Hanoi 100000, Vietnam
[2] Mayo Clin, Dept Radiat Oncol, Scottsdale, AZ USA
[3] Univ Lubeck, Dept Radiat Oncol, Lubeck, Germany
[4] Ha Noi Med Univ, Dept Nucl Med, Hanoi, Vietnam
来源
IN VIVO | 2017年 / 31卷 / 04期
关键词
High-grade gliomas; radiochemotherapy; temozolomide; clinical symptoms; performance status; survival score; PROGNOSTIC-FACTORS; BRAIN METASTASES; PREDICTING SURVIVAL; ADJUVANT TEMOZOLOMIDE; GLIOBLASTOMA; RADIOTHERAPY; RADIOSURGERY; CONCOMITANT; EXPRESSION; AUTOPHAGY;
D O I
10.21873/invivo.11114
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Aim: To create a simple survival score for patients with high-grade gliomas based on clinical symptoms and performance status. Patients and Methods: Thirty-six patients received neurosurgical intervention followed by radiochemotherapy for high-grade gliomas. Six pre-treatment symptoms were included in the score depending on their impairment of quality of life, scoring each between 1 and 3. For each patient, the points from the symptoms were added and another 4 points were added for Karnofsky performance status (KPS) <80%. Based on the survival rates of these scores, two groups were formed: 1-4 (group A) and 5-12 points (group B). Results: The 1-, 2- and 3-year survival rates in group A were 100%, 33% and 24% in group A and 47%, 7% and 0% in group B (p<0.001). In addition, complete tumor resection (p<0.001) and tumor grade III (p<0.001) were associated with improved survival. Conclusion: A simple survival score was developed helping physicians in decision-making for patients with high-grade gliomas.
引用
收藏
页码:689 / 693
页数:5
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