Changes in biochemical parameters related to atherosclerosis after Helicobacter pylori eradication
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作者:
Ando, T.
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Nagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, Japan
Ando, T.
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Minami, M.
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Nagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, Japan
Minami, M.
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Ishiguro, K.
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Nagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, Japan
Ishiguro, K.
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Maeda, O.
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Nagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, Japan
Maeda, O.
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Watanabe, O.
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Nagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, Japan
Watanabe, O.
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Mizuno, T.
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Nagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, Japan
Mizuno, T.
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Fujita, T.
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Nagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, Japan
Fujita, T.
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Takahashi, H.
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Nagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, Japan
Takahashi, H.
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Noshiro, M.
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Nagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, Japan
Noshiro, M.
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Goto, H.
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Nagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, JapanNagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, Japan
Goto, H.
[1
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[1] Nagoya Univ, Grad Sch Med, Dept Gastroenterol, Showa Ku, Nagoya, Aichi 4668550, Japan
Background Recent evidence suggests that Helicobacter pylori infection is involved in the pathogenesis of extra-gastrointestinal diseases such as coronary heart disease. Aim To determine the association of H. pylori infection with biochemical parameters of atherosclerosis in the serum. Methods One hundred and fifty-nine patients with H. pylori-positive peptic ulcer (duodenal ulcer, n=89; gastric ulcer, n=70) receiving triple therapy were studied prospectively for up to 3 years for clinical parameters associated with inflammation and cardiovascular events. Blood was tested at the time of annual check-up. Results Eradication was successful in 137 patients (86%), and body weight, body mass index (BMI) and TG levels increased gradually each year. No significant hanges were seen in plasma levels of total cholesterol, interleukin-6 or interleukin-8, whereas those of HDL-C increased significantly, and those of C-reactive protein, fibrinogen and LDL-C decreased. Conclusion There is evidence for the possible implication of H. pylori infection in the etiology of cardiovascular events via its exacerbation of or influence on risk factors of atherogenesis.
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Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, JapanFukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Azuma, T
Suto, H
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Suto, H
Ito, Y
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Ito, Y
Ohtani, M
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Ohtani, M
Dojo, M
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Dojo, M
Kuriyama, M
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Kuriyama, M
Kato, T
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
机构:Univ Roma La Sapienza, Policlin Umberto I, Sch Med 2,Dept Gastroenterol, Clin Med 2,Digest & Liver Dis Div, Rome, Italy
Capurso, G
Lahner, E
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机构:Univ Roma La Sapienza, Policlin Umberto I, Sch Med 2,Dept Gastroenterol, Clin Med 2,Digest & Liver Dis Div, Rome, Italy
Lahner, E
Marcheggiano, A
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Marcheggiano, A
Caruana, P
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Caruana, P
Carnuccio, A
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Carnuccio, A
Bordi, C
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Bordi, C
Delle Fave, G
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Delle Fave, G
Annibale, B
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Univ Roma La Sapienza, Policlin Umberto I, Sch Med 2,Dept Gastroenterol, Clin Med 2,Digest & Liver Dis Div, Rome, ItalyUniv Roma La Sapienza, Policlin Umberto I, Sch Med 2,Dept Gastroenterol, Clin Med 2,Digest & Liver Dis Div, Rome, Italy
机构:
Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, JapanFukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Azuma, T
Suto, H
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Suto, H
Ito, Y
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Ito, Y
Ohtani, M
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Ohtani, M
Dojo, M
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Dojo, M
Kuriyama, M
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Kuriyama, M
Kato, T
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
机构:Univ Roma La Sapienza, Policlin Umberto I, Sch Med 2,Dept Gastroenterol, Clin Med 2,Digest & Liver Dis Div, Rome, Italy
Capurso, G
Lahner, E
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机构:Univ Roma La Sapienza, Policlin Umberto I, Sch Med 2,Dept Gastroenterol, Clin Med 2,Digest & Liver Dis Div, Rome, Italy
Lahner, E
Marcheggiano, A
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机构:Univ Roma La Sapienza, Policlin Umberto I, Sch Med 2,Dept Gastroenterol, Clin Med 2,Digest & Liver Dis Div, Rome, Italy
Marcheggiano, A
Caruana, P
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机构:Univ Roma La Sapienza, Policlin Umberto I, Sch Med 2,Dept Gastroenterol, Clin Med 2,Digest & Liver Dis Div, Rome, Italy
Caruana, P
Carnuccio, A
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机构:Univ Roma La Sapienza, Policlin Umberto I, Sch Med 2,Dept Gastroenterol, Clin Med 2,Digest & Liver Dis Div, Rome, Italy
Carnuccio, A
Bordi, C
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机构:Univ Roma La Sapienza, Policlin Umberto I, Sch Med 2,Dept Gastroenterol, Clin Med 2,Digest & Liver Dis Div, Rome, Italy
Bordi, C
Delle Fave, G
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机构:Univ Roma La Sapienza, Policlin Umberto I, Sch Med 2,Dept Gastroenterol, Clin Med 2,Digest & Liver Dis Div, Rome, Italy
Delle Fave, G
Annibale, B
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Univ Roma La Sapienza, Policlin Umberto I, Sch Med 2,Dept Gastroenterol, Clin Med 2,Digest & Liver Dis Div, Rome, ItalyUniv Roma La Sapienza, Policlin Umberto I, Sch Med 2,Dept Gastroenterol, Clin Med 2,Digest & Liver Dis Div, Rome, Italy