Intracellular targeting of protein kinases and phosphatases

被引：33

作者：

Alto, N ^{[1
]}

Michel, JJC ^{[1
]}

Dodge, KL ^{[1
]}

Langeberg, LK ^{[1
]}

Scott, JD ^{[1
]}

机构：

[1] Howard Hughes Med Inst, Vollum Inst, Portland, OR 97201 USA

来源：

DIABETES | 2002年 / 51卷

关键词：

D O I：

10.2337/diabetes.51.2007.S385

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger-mediated signaling events.. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). This study focused on recent advances that further our understanding of AKAPs, with particular:emphasis on the bidirectional regulation of signaling events by AKAP-signaling complexes and their contribution to. the control of actin reorganization events.

引用

页码：S385 / S388

页数：4

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