Corneal angiogenic privilege and its failure

被引：45

作者：

Di Zazzo, Antonio ^{[1
]}

Gaudenzi, Daniele ^{[1
]}

Yin, Jia ^{[2
]}

Coassin, Marco ^{[1
]}

Fernandes, Merle ^{[3
]}

Dana, Reza ^{[2
]}

Bonini, Stefano ^{[1
]}

机构：

[1] Univ Campus Biomed, Ophthalmol Operat Complex Unit, Rome, Italy

[2] Harvard Med Sch, Dept Ophthalmol, Massachusetts Eye & Ear, Boston, MA 02115 USA

[3] LV Prasad Eye Inst, Cornea & Anterior Segment Serv, GMR Varalakshmi Campus, Visakhapatnam, Andhra Pradesh, India

来源：

EXPERIMENTAL EYE RESEARCH | 2021年 / 204卷

关键词：

ENDOTHELIAL GROWTH-FACTOR; MIGRATION INHIBITORY FACTOR; FACTOR-KAPPA-B; VEGF-A; T-CELLS; OCULAR ANGIOGENESIS; STROMAL CELLS; VESSEL GROWTH; NEOVASCULARIZATION; EXPRESSION;

D O I：

10.1016/j.exer.2021.108457

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The cornea actively maintains its own avascular status to preserve its ultimate optical function. This corneal avascular state is also defined as "corneal angiogenic privilege", which results from a critical and sensitive balance between anti-angiogenic and pro-angiogenic mechanisms. In our review, we aim to explore the complex equilibrium among multiple mediators which prevents neovascularization in the resting cornea, as well as to unveil the evolutive process which leads to corneal angiogenesis in response to different injuries.

引用

页数：10

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