Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

被引：857
作者：
Kisler, Kassandra [1 ]
Nelson, Amy R. [1 ]
Montagne, Axel [1 ]
Zlokovic, Berislav V. [1 ]
机构：
[1] Zilkha Neurogenet Inst, 1501 San Pablo St, Los Angeles, CA 90089 USA
来源：
NATURE REVIEWS NEUROSCIENCE | 2017年 / 18卷 / 07期
基金：
美国国家卫生研究院;
关键词：
PERICYTE-CONTAINING MICROVASCULATURE; AUTOSOMAL-DOMINANT ARTERIOPATHY; BRAIN-BARRIER PERMEABILITY; POSTERIOR CINGULATE CORTEX; RECEPTOR-RELATED PROTEIN-1; DEFAULT-MODE NETWORK; ANGIOTENSIN-II; MOUSE MODEL; FUNCTIONAL CONNECTIVITY; APOLIPOPROTEIN-E;
D O I：
10.1038/nrn.2017.48
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian brain has evolved a unique mechanism for CBF control known as neurovascular coupling. This mechanism ensures a rapid increase in the rate of CBF and oxygen delivery to activated brain structures. The neurovascular unit is composed of astrocytes, mural vascular smooth muscle cells and pericytes, and endothelia, and regulates neurovascular coupling. This Review article examines the cellular and molecular mechanisms within the neurovascular unit that contribute to CBF control, and neurovascular dysfunction in neurodegenerative disorders such as Alzheimer disease.
引用
收藏
页码：419 / 434
页数：16
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