EFFICACY OF THE 7-VALENT PNEUMOCOCCAL CONJUGATE VACCINE AGAINST ACUTE OTITIS MEDIA CAUSED BY SEROTYPE 6C PNEUMOCOCCUS

被引：7

作者：

Palmu, Arto A. ^{[1
]}

Kaijalainen, Tarja ^{[1
]}

Jokinen, Jukka ^{[1
]}

Kilpi, Terhi M. ^{[1
]}

机构：

[1] Natl Inst Hlth & Welf, Dept Hlth Protect, Helsinki, Finland

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2015年 / 34卷 / 07期

关键词：

conjugate vaccine; pneumococcus; clinical trial; infant; serotype; 6C; STREPTOCOCCUS-PNEUMONIAE; POLYSACCHARIDES; 13-VALENT; CHILDREN; 6A;

D O I：

10.1097/INF.0000000000000728

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A new pneumococcal serotype 6C, earlier typed as 6A, was discovered in 2007. We retyped all 6A isolates to evaluate vaccine efficacy against 6C acute otitis media (AOM) in the phase III randomized, doubleblind Finnish Otitis Media trial conducted in 1995-1999. Efficacy against 6C AOM was -1 (95% confidence interval: -248 to 71) during the per protocol follow-up period. The updated vaccine efficacy estimate for serotype 6A AOM was 65% (95% confidence interval: 31-82). Seven-valent pneumococcal conjugate vaccine offered excellent cross-protection against 6A AOM, but our data do not support cross-protection against 6C AOM.

引用

页码：796 / 797

页数：2

共 13 条

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