Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability

被引：8
|
作者：
Wang, Bin [1 ]
Pan, Rizhao [1 ]
Zhu, Weiping [1 ]
Xu, Yufang [1 ]
Tian, Ye [2 ]
Endo, Masayuki [3 ]
Sugiyama, Hiroshi [3 ]
Yang, Yangyang [1 ]
Qian, Xuhong [1 ,4 ]
机构：
[1] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
[2] Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210093, Peoples R China
[3] Kyoto Univ, Dept Chem, Kitashirakawa Oiwakecho, Kyoto 6068502, Japan
[4] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
来源：
SOFT MATTER | 2021年 / 17卷 / 05期
基金：
中国国家自然科学基金;
关键词：
50;
D O I：
10.1039/d0sm01817a
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their contraction and expansion. Furthermore, the nanospheres showed biocompatibility, drug encapsulation and effective cellular uptake.
引用
收藏
页码：1184 / 1188
页数：5
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