Inotuzumab ozogamicin in infants and young children with relapsed or refractory acute lymphoblastic leukaemia: a case series*

被引：16

作者：

Brivio, Erica ^{[1
,2
]}

Chantrain, Christophe F. ^{[3
]}

Gruber, Tanja A. ^{[4
,5
]}

Thano, Adriana ^{[1
]}

Rialland, Fanny ^{[6
]}

Contet, Audrey ^{[7
]}

Elitzur, Sarah ^{[8
]}

Dalla-Pozza, Luciano ^{[9
]}

Kallay, Krisztian Miklos ^{[10
]}

Li, Chi-kong ^{[11
]}

Kato, Motohiro ^{[12
]}

Markova, Inna ^{[13
]}

Schmiegelow, Kjeld ^{[14
,15
]}

Bodmer, Nicole ^{[16
]}

Breese, Erin H. ^{[17
,18
]}

Hoogendijk, Raoull ^{[1
]}

Pieters, Rob ^{[1
]}

Zwaan, Christian Michel ^{[1
,2
]}

机构：

[1] Princess Maxima Ctr Pediat Oncol, Heidelberglaan 25, NL-3584 CS Utrecht, Netherlands

[2] Erasmus MC Sophia Childrens Hosp, Dept Pediat Oncol Hematol, Rotterdam, Netherlands

[3] CHC Clin Mt Legia Liege, Div Pediat Hematol Oncol, Liege, Belgium

[4] Stanford Sch Med, Dept Pediat, Stanford, CA 94305 USA

[5] Stanford Sch Med, Stanford Canc Inst, Stanford, CA 94305 USA

[6] CHU Nantes, Dept Oncol & Hematol, Nantes, France

[7] CHRU Nancy, Dept Oncol & Hematol, Childrens Hosp, Vandoeuvre Les Nancy, France

[8] Tel Aviv Univ, Sackler Fac Med, Schneider Childrens Med Ctr Israel, Pediat Hematol Oncol, Tel Aviv, Israel

[9] Childrens Hosp Westmead, Canc Ctr Children, Westmead, NSW, Australia

[10] Cent Hosp Southern Pest, Pediat Hematol & Stem Cell Transplantat Dept, Natl Inst Hematol & Infect Dis, Budapest, Hungary

[11] Chinese Univ Hong Kong, Dept Paediat, Hong Kong, Peoples R China

[12] Natl Res Inst Child Hlth & Dev, Dept Pediat Hematol & Oncol Res, Tokyo, Japan

[13] Pavlov Univ, RM Gorbacheva Mem Inst Children Oncol Hematol & T, St Petersburg, Russia

[14] Copenhagen Univ Hosp, Dept Pediat & Adolescent Med, Rigshosp, Copenhagen, Denmark

[15] Univ Copenhagen, Fac Hlth, Inst Clin Med, Copenhagen, Denmark

[16] Univ Childrens Hosp Zurich, Dept Oncol, Zurich, Switzerland

[17] Cincinnati Childrens Hosp Med Ctr, Div Oncol, Canc & Blood Dis Inst, Cincinnati, OH 45229 USA

[18] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2021年 / 193卷 / 06期

关键词：

infants; ALL; inotuzumab ozogamicin;

D O I：

10.1111/bjh.17333

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

No data on inotuzumab ozogamicin (InO) in infant acute lymphoblastic leukaemia (ALL) have been published to date. We collected data internationally on infants/young children (<3 years) with ALL treated with InO. Fifteen patients (median 4.4 months at diagnosis) received InO due to relapsed or refractory (R/R) disease. Median percentage of CD22(+) blasts was 72% (range 40-100%, n = 9). The median dose in the first course was 1.74 mg/m(2) (fractionated). Seven patients (47%) achieved complete remission; one additional minimal residual disease (MRD)-positive patient became MRD-negative. Six-month overall survival was 47% (95% confidence interval [CI] 27-80%). Two patients developed veno-occlusive disease after transplant. Further evaluation of InO in this subgroup of ALL is justified.

引用

页码：1172 / 1177

页数：6

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