Molecular mimicry between gangliosides and lipopolysaccharides of Campylobacter jejuni isolated from patients with Guillain-Barre syndrome and Miller Fisher syndrome

被引：98
作者：
Yuki, N
机构：
来源：
JOURNAL OF INFECTIOUS DISEASES | 1997年 / 176卷
关键词：
D O I：
10.1086/513800
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Some patients developed Guillain-Barre syndrome (GES) after being given bovine gangliosides. Patients with GBS subsequent to Campylobacter jejuni enteritis frequently have IgG antibody to GM(1) ganglioside. Miller Fisher syndrome (MFS), a variant of GBS. is associated with IgG antibody to GQ(1b) ganglioside. The existence of molecular mimicry between GM(1) and lipopolysaccharide of C. jejuni isolated from a GBS patient and that between GQ(1b) and C. jejuni lipopolysaccharides from patients with MFS are shown herein. The molecular mimicry between infectious agents and gangliosides may function in the production of anti-ganglioside antibodies and the development of GBS and MFS.
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页码：S150 / S153
页数：4
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