Synthesis and Enzymatic Degradation of Soft Aliphatic Polyesters

被引：18

作者：

Buchholz, Viola ^{[1
,2
]}

Agarwal, Seema ^{[1
,2
]}

Greiner, Andreas ^{[1
,2
]}

机构：

[1] Univ Bayreuth, Macromol Chem 2, POB 101251, D-95440 Bayreuth, Germany

[2] Univ Bayreuth, Bayreuth Ctr Colloids & Interfaces, POB 101251, D-95440 Bayreuth, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2016年 / 16卷 / 02期

关键词：

degradation; mechanical properties; polycondensation; thermal properties; EPSILON-DECALACTONE; CRYSTALLINITY; POLYCAPROLACTONE; ADIPATE); POLYMERS; FILMS;

D O I：

10.1002/mabi.201500279

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel aliphatic enzymatically degradable polyesters with short alkyl side chains for tuning crystallinity are presented in this work. The intrinsic problem of aliphatic polyesters is their brittleness and tendency to crystallize. This was modulated by the synthesis of random copolyesters based on aliphatic linear monomers, adipic acid, 1,5-pentanediol and monomers with aliphatic branches, such as 2-butyl-2-ethyl-1,3-propanediol by polycondensation. The resulting copolyesters were crystalline, wax-like or had liquid texture with varied mechanical properties and enzymatic degradability depending upon the copolymer composition. Such polyesters are of significant interest for a wide range of possible applications such as controlled drug delivery, agricultural applications and as packing materials.

引用

页码：207 / 213

页数：7

共 23 条

[1] Biodegradability of poly(tetramethylene succinate-co-tetramethylene adipate): I. Enzymatic hydrolysis [J].