Prospective analysis of circulating metabolites and breast cancer in EPIC

被引：82

作者：

His, Mathilde ^{[1
]}

Viallon, Vivian ^{[1
]}

Dossus, Laure ^{[1
]}

Gicquiau, Audrey ^{[1
]}

Achaintre, David ^{[1
]}

Scalbert, Augustin ^{[1
]}

Ferrari, Pietro ^{[1
]}

Romieu, Isabelle ^{[2
]}

Onland-Moret, N. Charlotte ^{[3
]}

Weiderpass, Elisabete ^{[1
]}

Dahm, Christina C. ^{[4
]}

Overvad, Kim ^{[4
,5
]}

Olsen, Anja ^{[6
]}

Tjonneland, Anne ^{[6
,7
]}

Fournier, Agnes ^{[8
,9
]}

Rothwell, Joseph A. ^{[8
,9
]}

Severi, Gianluca ^{[8
,9
]}

Kuehn, Tilman ^{[10
]}

Fortner, Renee T. ^{[10
]}

Boeing, Heiner ^{[11
]}

Trichopoulou, Antonia ^{[12
]}

Karakatsani, Anna ^{[12
,13
]}

Martimianaki, Georgia ^{[12
]}

Masala, Giovanna ^{[14
]}

Sieri, Sabina ^{[15
]}

Tumino, Rosario ^{[16
,17
]}

Vineis, Paolo ^{[18
,19
]}

Panico, Salvatore ^{[20
]}

van Gils, Carla H. ^{[3
]}

Nost, Therese H. ^{[21
]}

Sandanger, Torkjel M. ^{[21
]}

Skeie, Guri ^{[21
,22
]}

Quiros, J. Ramon ^{[23
]}

Agudo, Antonio ^{[24
]}

Sanchez, Maria-Jose ^{[25
,26
]}

Amiano, Pilar ^{[26
,27
]}

Maria Huerta, Jose ^{[26
,28
]}

Ardanaz, Eva ^{[26
,29
,30
]}

Schmidt, Julie A. ^{[31
]}

Travis, Ruth C. ^{[31
]}

Riboli, Elio ^{[32
]}

Tsilidis, Konstantinos K. ^{[32
,33
]}

Christakoudi, Sofia ^{[32
,34
]}

Gunter, Marc J. ^{[1
]}

Rinaldi, Sabina ^{[1
]}

机构：

[1] Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon 08, France

[2] Natl Inst Publ Hlth, Ctr Res Populat Hlth, Cuernavaca, Morelos, Mexico

[3] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[4] Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark

[5] Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark

[6] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[7] Univ Copenhagen, Copenhagen, Denmark

[8] Univ Paris Saclay, Univ Paris Sud, CESP, UVSQ,INSERM, Villejuif, France

[9] Gustave Roussy, Villejuif, France

[10] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[11] German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Epidemiol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany

[12] Hellen Hlth Fdn, Athens, Greece

[13] Natl & Kapodistrian Univ Athens, ATTIKON Univ Hosp, Sch Med, Pulm Med Dept, Haidari, Greece

[14] Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[15] Fdn IRCCS Ist Nazl Tumori Milano, Epidemiol & Prevent Unit, Milan, Italy

[16] MP Arezzo Hosp, ASP Ragusa, Canc Registry, Ragusa, Italy

[17] MP Arezzo Hosp, ASP Ragusa, Histopathol Dept, Ragusa, Italy

[18] IIGM, I-10126 Turin, Italy

[19] Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London, England

[20] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[21] UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway

[22] Univ Leeds, Sch Food Sci & Nutr, Nutr Epidemiol Grp, Leeds, W Yorkshire, England

[23] Publ Hlth Directorate, Asturias, Spain

[24] Catalan Inst Oncol IDIBELL, Unit Nutr & Canc, Canc Epidemiol Res Program, Barcelona, Spain

[25] Univ Granada, Inst Invest Biosanitaria Ibs GRANADA, Escuela Andaluza Salud Publ, Granada, Spain

[26] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain

[27] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[28] Murcia Reg Hlth Council, Dept Epidemiol, IMIB Arrixaca, Murcia, Spain

[29] Navarra Publ Hlth Inst, Pamplona, Spain

[30] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain

[31] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England

[32] Imperial Coll London, Dept Epidemiol & Biostat, St Marys Campus,Norfolk Pl, London W2 1PG, England

[33] Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece

[34] Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England

来源：

BMC MEDICINE | 2019年 / 17卷 / 01期

基金：

英国医学研究理事会; 瑞典研究理事会; 欧洲研究理事会;

关键词：

Breast cancer; Metabolomics; Prospective study; BODY-MASS INDEX; METABOLOMIC PROFILES; RISK; WOMEN; SEX;

D O I：

10.1186/s12916-019-1408-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in plasma and breast cancer risk. Methods A nested case-control study was established within the European Prospective Investigation into Cancer cohort, which included 1624 first primary incident invasive breast cancer cases (with known estrogen and progesterone receptor and HER2 status) and 1624 matched controls. Metabolites (n = 127, acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexose, sphingolipids) were measured by mass spectrometry in pre-diagnostic plasma samples and tested for associations with breast cancer incidence using multivariable conditional logistic regression. Results Among women not using hormones at baseline (n = 2248), and after control for multiple tests, concentrations of arginine (odds ratio [OR] per SD = 0.79, 95% confidence interval [CI] = 0.70-0.90), asparagine (OR = 0.83 (0.74-0.92)), and phosphatidylcholines (PCs) ae C36:3 (OR = 0.83 (0.76-0.90)), aa C36:3 (OR = 0.84 (0.77-0.93)), ae C34:2 (OR = 0.85 (0.78-0.94)), ae C36:2 (OR = 0.85 (0.78-0.88)), and ae C38:2 (OR = 0.84 (0.76-0.93)) were inversely associated with breast cancer risk, while the acylcarnitine C2 (OR = 1.23 (1.11-1.35)) was positively associated with disease risk. In the overall population, C2 (OR = 1.15 (1.06-1.24)) and PC ae C36:3 (OR = 0.88 (0.82-0.95)) were associated with risk of breast cancer, and these relationships did not differ by breast cancer subtype, age at diagnosis, fasting status, menopausal status, or adiposity. Conclusions These findings point to potentially novel pathways and biomarkers of breast cancer development. Results warrant replication in other epidemiological studies.

引用

页数：13

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