Neutrophil elastase-mediated killing of bacteria: lessons from targeted mutagenesis

被引：67
作者：
Belaaouaj, A [1 ]
机构：
[1] Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Med,Pulm Div, St Louis, MO 63110 USA
来源：
MICROBES AND INFECTION | 2002年 / 4卷 / 12期
关键词：
neutrophil elastase; neutrophil; bacteria; gene targeting;
D O I：
10.1016/S1286-4579(02)01654-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Engineering of mice deficient in neutrophil elastase (NE) has allowed us to demonstrate the role of this protease in host defense against bacteria and to begin to understand its killing mechanism. Strategies to inhibit NE because of its involvement in tissue-destructive diseases should be reconsidered, while preserving its beneficial properties. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：1259 / 1264
页数：6
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