Raltegravir: is a 400 mg once-daily dose enough?

被引:6
作者
Lanzafame, Massimiliano [1 ]
Hill, Andrew [2 ]
Lattuada, Emanuela [1 ]
Calcagno, Andrea [3 ]
Bonora, Stefano [3 ]
机构
[1] GB Rossi Hosp, Unit Diag & Therapy HIV Infect, I-37134 Verona, Italy
[2] Univ Liverpool, Pharmacol Res Labs, Liverpool L69 3GF, Merseyside, England
[3] Amedeo di Savoia Hosp, Dept Infect Dis, I-101159 Turin, Italy
关键词
atazanavir; HAART; HIV infection; pharmacokinetics; INTEGRASE INHIBITOR RALTEGRAVIR; RANDOMIZED CONTROLLED-TRIAL; TREATMENT-NAIVE PATIENTS; HIV-1; INTEGRASE; COMBINATION THERAPY; SAFETY; PHARMACOKINETICS; TOLERABILITY; INFECTION; EFFICACY;
D O I
10.1093/jac/dkp488
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
引用
收藏
页码:595 / 597
页数:3
相关论文
共 6 条
[1]   Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial [J].
Grinsztejn, Beatriz ;
Nguyen, Bach-Yen ;
Katlama, Christine ;
Gatell, Jose M. ;
Lazzarin, Adriano ;
Vittecoq, Daniel ;
Gonzalez, Charles J. ;
Chen, Joshua ;
Harvey, Charlotte M. ;
Isaacs, Robin D. .
LANCET, 2007, 369 (9569) :1261-1269
[2]   Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects [J].
Iwamoto, M. ;
Wenning, L. A. ;
Petry, A. S. ;
Laethem, M. ;
De Smet, M. ;
Kost, J. T. ;
Merschman, S. A. ;
Strohmaier, K. M. ;
Ramael, S. ;
Lasseter, K. C. ;
Stone, J. A. ;
Gottesdiener, K. M. ;
Wagner, J. A. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2008, 83 (02) :293-299
[3]   Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial [J].
Lennox, Jeffrey L. ;
Dejesus, Edwin ;
Lazzarin, Adriano ;
Pollard, Richard B. ;
Ramalho Madruga, Jose Valdez ;
Berger, Daniel S. ;
Zhao, Jing ;
Xu, Xio ;
Williams-Diaz, Angela ;
Rodgers, Anthony J. ;
Barnard, Richard J. O. ;
Miller, Michael D. ;
DiNubile, Mark J. ;
Nguyen, Bach-Yen ;
Leavitt, Randi ;
Sklar, Peter .
LANCET, 2009, 374 (9692) :796-806
[4]   Rapid and durable Antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection - Results of a 48-week controlled study [J].
Markowitz, Martin ;
Nguyen, Bach-Yen ;
Gotuzzo, Eduardo ;
Mendo, Fernando ;
Ratanasuwan, Winai ;
Kovacs, Colin ;
Prada, Guillermo ;
Morales-Ramirez, Javier O. ;
Crumpacker, Clyde S. ;
Isaacs, Robin D. ;
Gilde, Lucinda R. ;
Wan, Hong ;
Miller, Michael D. ;
Wenning, Larissa A. ;
Teppler, Hedy .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2007, 46 (02) :125-133
[5]   Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals [J].
Markowitz, Martin ;
Morales-Ramirez, Javier O. ;
Nguyen, Bach-Yen ;
Kovacs, Colin M. ;
Steigbigel, Roy T. ;
Cooper, David A. ;
Liporace, Ralph ;
Schwartz, Robert ;
Isaacs, Robin ;
Gilde, Lucinda R. ;
Penning, Larissa ;
Zhao, Jing ;
Teppler, Hedy .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2006, 43 (05) :509-515
[6]  
NEELY M, 2009, 5 IAS C HIV PATH CAP