Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate

被引：249

作者：

Chakrabarty, Ram Prosad ^{[1
]}

Chandel, Navdeep S. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Med Biochem & Mol Genet, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

CELL STEM CELL | 2021年 / 28卷 / 03期

关键词：

METABOLIC-REGULATION; SELF-RENEWAL; ONCOMETABOLITE; 2-HYDROXYGLUTARATE; EPIGENETIC CONTROL; GENE-EXPRESSION; ROS LEVELS; LIFE-SPAN; DIFFERENTIATION; PLURIPOTENCY; OXYGEN;

D O I：

10.1016/j.stem.2021.02.011

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Recent evidence supports the notion that mitochondrial metabolism is necessary for the determination of stem cell fate. Historically, mitochondrial metabolism is linked to the production of ATP and tricarboxylic acid (TCA) cycle metabolites to support stem cell survival and growth, respectively. However, it is now clear that beyond these canonical roles, mitochondria as signaling organelles dictate stem cell fate and function. In this review, we focus on key conceptual ideas on how mitochondria control mammalian stem cell fate and function through reactive oxygen species (ROS) generation, TCA cycle metabolite production, NAD(+)/NADH ratio regulation, pyruvate metabolism, and mitochondrial dynamics.

引用

页码：394 / 408

页数：15

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