Rapid cycling bipolar affective disorder: lack of relation to hypothyroidism

被引:39
作者
Post, RM
Kramlinger, KG
Joffe, RT
RoyByrne, PP
Rosoff, A
Frye, MA
Huggins, T
机构
[1] MAYO CLIN & MAYO FDN, MAYO MED SCH, DEPT PSYCHIAT, ROCHESTER, MN 55905 USA
[2] MCMASTER UNIV, MED CTR, DEPT PSYCHIAT, HAMILTON, ON, CANADA
[3] UNIV WASHINGTON, HARBORVIEW MED CTR, DEPT PSYCHIAT, SEATTLE, WA 98104 USA
关键词
affective disorder; rapid cycling; hypothyroidism; thyroxine; triiodothyronine; lithium;
D O I
10.1016/S0165-1781(97)00076-0
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Thyroid indices were measured after an extended period of medication-free evaluation averaging 6 weeks in 67 consecutively admitted patients with bipolar illness. Thyroid hormone levels - thyroxine (T-4), free T-4 and triiodothyronine (T-3) - were not significantly different in the 31 rapid cyclers (greater than or equal to 4 affective episodes/year) than in 36 non-rapid cyclers. Analysis of covariance indicated a non-significant trend relation between higher T-4 and a greater number of affective episodes in the year prior to admission and male gender when age was covaried. Several previous reports, primarily in medicated subjects, have suggested a link between rapid cycling patients and decreased peripheral thyroid indices (low hormone levels and elevated TSH), but now the majority of studies do not support such a relation. Among those in the literature, this study includes patients studied for the longest time off medications and further suggests that the commonly-cited relation between subclinical hypothyroidism and rapid cycling bipolar illness be reevaluated. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:1 / 7
页数:7
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