Distribution of ABO genotypes and allele frequencies in a Korean population

被引：29
作者：
Kang, SH
Fukumori, Y
Ohnoki, S
Shibata, H
Han, KS
Nishimukai, H
Okubo, Y
机构：
[1] OSAKA RED CROSS BLOOD CTR,JOTO KU,OSAKA 536,JAPAN
[2] HALLYM UNIV HOSP,DEPT CLIN PATHOL,CHUNCHON 200060,KANGWON DO,SOUTH KOREA
[3] SEOUL NATL UNIV,DEPT CLIN PATHOL,COLL MED,SEOUL 110744,SOUTH KOREA
[4] EHIME UNIV,SCH MED,DEPT LEGAL MED,SHIGENOBU,EHIME 79102,JAPAN
来源：
JAPANESE JOURNAL OF HUMAN GENETICS | 1997年 / 42卷 / 02期
关键词：
ABO blood group; genotyping; PCR-RFLP; Korean population;
D O I：
10.1007/BF02766955
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The genotypes of the ABO blood group system were investigated in Korean living in Kangwon-Do area by PCR-RFLP analysis of the seven polymorphic nucleotide positions 261, 467, 526, 646, 703, 796 and 803 of the cDNA from A, transferase. In 253 unrelated Korean individuals, 15 genotypes were found and the allele frequencies of A(Pro), A(Leu), B, O(T) and O(A) were 0.022, 0.209, 0.209, 0.360 and 0.200, respectively, with no deviation from Hardy-Weinberg expectations (chi(2)=2.145, d.f.=6, 0.90<p<0.95). As for the distribution of allele frequencies, a significant difference was noticed between the Korean and a Japanese (chi(2)=30.87, d.f.=4, p<0.001) and a German (chi(2)=127.76,d.f.=4, p < 0.001) populations.
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页码：331 / 335
页数：5
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