Hypothalamic lipid-laden astrocytes induce microglia migration and activation

被引：63

作者：

Kwon, Yoon-Hee ^{[1
]}

Kim, Jiye ^{[1
]}

Kim, Chu-Sook ^{[1
]}

Tu, Thai Hien ^{[1
]}

Kim, Min-Seon ^{[2
,3
]}

Suk, Kyoungho ^{[4
]}

Kim, Dong Hee ^{[5
]}

Lee, Byung Ju ^{[5
]}

Choi, Hye-Seon ^{[5
]}

Park, Taesun ^{[6
]}

Choi, Myung-Sook ^{[7
]}

Goto, Tsuyoshi ^{[8
]}

Kawada, Teruo ^{[8
]}

Ha, Tae Youl ^{[9
]}

Yu, Rina ^{[1
]}

机构：

[1] Univ Ulsan, Dept Food Sci & Nutr, 93 Daehak Ro, Ulsan, South Korea

[2] Asan Inst Life Sci, Appetite Regulat Lab, Seoul, South Korea

[3] Univ Ulsan, Coll Med, Div Endocrinol & Metab, Seoul, South Korea

[4] Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu, South Korea

[5] Univ Ulsan, Dept Biol Sci, Ulsan, South Korea

[6] Yonsei Univ, Dept Food & Nutr, Seoul, South Korea

[7] Kyungpook Natl Univ, Dept Food Sci & Nutr, Ctr Food & Nutr Genom Res, Daegu, South Korea

[8] Kyoto Univ, Grad Sch Agr, Uji, Kyoto, Japan

[9] Korea Food Res Inst, Res Grp Nutr & Metab Syst, Seongnam, South Korea

来源：

FEBS LETTERS | 2017年 / 591卷 / 12期

关键词：

astrocyte; hypothalamus; inflammation; obesity; MONOCYTE CHEMOATTRACTANT PROTEIN-1; FATTY-ACID UPTAKE; OBESITY; BRAIN; INFLAMMATION; DIET; METABOLISM; EXPRESSION; GLIOSIS; CELLS;

D O I：

10.1002/1873-3468.12691

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity-induced hypothalamic inflammation is closely associated with various metabolic complications and neurodegenerative disorders. Astrocytes, the most abundant glial cells in the central nervous system, play a crucial role in pathological hypothalamic inflammatory processes. Here, we demonstrate that hypothalamic astrocytes accumulate lipid droplets under saturated fatty acid-rich conditions, such as obese environment, and that the lipid-laden astrocytes increase astrogliosis markers and inflammatory cytokines (TNF alpha, IL-1 beta, IL-6, MCP-1) at the transcript and/or protein level. Medium conditioned by the lipid-laden astrocytes stimulate microglial chemotactic activity and upregulate transcripts of the microglia activation marker Iba-1 and inflammatory cytokines. These findings indicate that the lipid-laden astrocytes formed in free fatty acid-rich obese condition may participate in obesity-induced hypothalamic inflammation through promoting microglia migration and activation.

引用

页码：1742 / 1751

页数：10

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