The cyclic deformation and lifetime behaviour of the cast Ni-base superalloy IN 792 CC was investigated both under thermal-mechanical fatigue (TMF) and isothermal fatigue (IF) conditions. During TMF the phase relations between temperature and mechanical strain were in-phase and out-of-phase, respectively. For both phase relations a similar cyclic deformation behaviour is observed. In all cases out-of-phase TMF causes tensile mean stresses, whereas in-phase TMF leads to compressive mean stresses. At T-max below 800 degrees C out-of-phase cycling results in smaller lifetimes than in-phase loading. In spite of the rather high compressive mean stresses developing at T-max above 800 degrees C, at these temperatures in-phase loading causes shorter lifetimes than out-of-phase TMF. This effect is due to the different damage mechanisms caused by in-phase and out-of-phase loadings: al higher T-max considerable intergranular damage caused by in-phase loading reduces the lifetime below the respective values measured during out-of-phase TMF, after which no intergranular damage could be detected. A comparison of the TMF data with the cyclic deformation and lifetime behaviour under IF conditions shows that the material's reactions under TMF cannot be assessed satisfactorily by the results obtained from isothermal fatigue tests. (C) 1997 Elsevier Science S.A.