A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria

被引：23

作者：

Dai, Hao-Fu ^{[1
]}

Gan, Yu-Juan ^{[1
]}

Que, Dong-Mei ^{[1
]}

Wu, Jiao ^{[1
]}

Wen, Zhen-Chang ^{[2
]}

Mei, Wen-Li ^{[1
]}

机构：

[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Trop Crop Biotechnol, Haikou, Peoples R China

[2] Hainan Univ, Minist Educ, Key Lab Trop Biol Resources, Haikou 570228, Peoples R China

来源：

MOLECULES | 2009年 / 14卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Antiaris toxicaria; toxicarioside H; nor-cardenolide; cytotoxicity; DART POISONS;

D O I：

10.3390/molecules14093694

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by MTT method.

引用

页码：3694 / 3699

页数：6

共 9 条

[1]

BISSET NG, 1966, LLOYD, V29, P1

[2] Toxicarioside A. A new cardenolide isolated from Antiaris toxicaria latex-derived dart poison. Assignment of the H-1- and C-13-NMR shifts for an antiarigenin aglycone. [J].