The emerging field of epigenetics in neurodegeneration and neuroprotection

被引：259

作者：

Hwang, Jee-Yeon ^{[1
]}

Aromolaran, Kelly A. ^{[1
]}

Zukin, R. Suzanne ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, Rose F Kennedy Ctr, Room 610,1300 Morris Pk Ave, Bronx, NY 10461 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2017年 / 18卷 / 06期

基金：

美国国家卫生研究院;

关键词：

RUBINSTEIN-TAYBI-SYNDROME; TRANSCRIPTION FACTOR REST; SCF-BETA-TRCP; SUBEROYLANILIDE HYDROXAMIC ACID; HISTONE DEACETYLASE INHIBITION; GENOME-WIDE ANALYSIS; LONG NONCODING RNA; ALZHEIMERS-DISEASE; DNA METHYLATION; HUNTINGTONS-DISEASE;

D O I：

10.1038/nrn.2017.46

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Epigenetic mechanisms - including DNA methylation, histone post-translational modifications and changes in nucleosome positioning - regulate gene expression, cellular differentiation and development in almost all tissues, including the brain. In adulthood, changes in the epigenome are crucial for higher cognitive functions such as learning and memory. Striking new evidence implicates the dysregulation of epigenetic mechanisms in neurodegenerative disorders and diseases. Although these disorders differ in their underlying causes and pathophysiologies, many involve the dysregulation of restrictive element 1-silencing transcription factor (REST), which acts via epigenetic mechanisms to regulate gene expression. Although not somatically heritable, epigenetic modifications in neurons are dynamic and reversible, which makes them good targets for therapeutic intervention.

引用

页码：347 / 361

页数：15

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