Determination of ethamsylate in pharmaceutical preparations based on an auto-oxidation chemiluminescence reaction

被引：33

作者：

Yang, FZ

Zhang, C

Baeyens, WRG

Zhang, XR ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

[2] Univ Ghent, Fac Pharmaceut Sci, B-9000 Ghent, Belgium

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2002年 / 30卷 / 03期

基金：

中国国家自然科学基金;

关键词：

ethamsylate; dissolved oxygen; Tween; 80; rhodamine; 6G; chemiluminescence;

D O I：

10.1016/S0731-7085(02)00096-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Strong chemiluminescence emission has been observed by mixing alkaline hydrolytic products of ethamsylate with Tween 80 in acidic rhodamine 6G solution. This phenomenon has been utilized to design a flow-injection chemiluminescence method for the determination of ethamsylate in a pharmaceutical preparation. Under the optimum conditions, the proposed procedure has a linear range between 0.05 and 2.0 mug ml(-1), with a detection limit of 0.02 mug ml(-1) for ethamsylate. The method was applied to the determination of ethamsylate in pharmaceutical preparations. The possible mechanism of this chemiluminescence reaction was proposed. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：473 / 478

页数：6

共 6 条

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