Synthesis of the DE synthon of racemic camptothecin

被引：4

作者：

Yu, Shanbao ^{[1
]}

Luo, Yu ^{[1
]}

Liu, Haiyan ^{[1
]}

Liu, Haomin ^{[1
]}

Lu, Wei ^{[1
]}

机构：

[1] E China Normal Univ, Dept Chem, Inst Med Chem, Shanghai 200062, Peoples R China

来源：

MONATSHEFTE FUR CHEMIE | 2010年 / 141卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Pyridone; Lactone; 2-Chloronicotinic acid; Lithiation; Camptothecin; EFFICIENT TOTAL-SYNTHESIS; PLANT ANTITUMOR AGENTS; TOPOISOMERASE-I; BIOLOGICAL EVALUATION; DIRECTED LITHIATION; 6-STEP SYNTHESIS; METALATION; 14-AZACAMPTOTHECIN; (+)-CAMPTOTHECIN; REPLICATION;

D O I：

10.1007/s00706-009-0245-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A concise formal synthesis of camptothecin is described. The key pyrido-lactone (DE ring) was prepared effectively starting from 2-chloronicotinic acid via lithiation, reduction, and hydrolysis in 29% overall yield.

引用

页码：245 / 249

页数：5

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