Prevalence of fundus tessellation and its associated factors in Chinese children and adolescents with high myopia

被引:37
作者
Cheng, Tianyu [1 ,2 ]
Deng, Junjie [2 ]
Xu, Xian [2 ]
Zhang, Bo [1 ]
Wang, Jingjing [1 ]
Xiong, Shuyu [2 ]
Du, Yuchen [2 ]
Yu, Suqin [2 ]
Gong, Wei [2 ]
Zhao, Huijuan [1 ]
Luan, Mengli [1 ]
Fan, Ying [2 ]
Zhu, Jianfeng [1 ]
Zou, Haidong [1 ,2 ]
Xu, Xun [1 ,2 ]
He, Xiangui [1 ,2 ]
机构
[1] Shanghai Eye Hosp, Shanghai Eye Dis Prevent & Treatment Ctr, Shanghai Children & Adolescent Myopia Prevent & T, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Dept Ophthalmol,Shanghai Gen Hosp,Sch Med, Natl Clin Res Ctr Eye Dis,Shanghai Key Lab Ocular, Shanghai Engn Ctr Visual Sci & Photomed,Shanghai, Shanghai, Peoples R China
关键词
children; choroidal thickness; fundus tessellation; grading; high myopia; CHOROIDAL THICKNESS; OPTIC DISC; BLINDNESS; POPULATION; SHANGHAI; TILT;
D O I
10.1111/aos.14826
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose To investigate the prevalence and associated factors of fundus tessellation in highly myopic children and adolescents. Methods A total of 513 high myopes (spherical equivalent [SE] <= -5.0 D, 4-19 years of age) without any advanced pathological myopic lesions were enrolled. Fundus photographs and choroidal thickness (ChT) data were collected by SS-OCT. A novel grading approach was adopted to classify fundus tessellation into four categories on colour fundus photography, referring to the location of tessellation divided by an Early Treatment Diabetic Retinopathy Study grid centred on the fovea, through which closer to the fovea represents higher grades of fundus tessellation. Peripapillary atrophy (PPA) area and ovality index were also measured. Results Among the participants, with a mean age of 13.47 +/- 3.13 years and mean SE of - 8.34 +/- 1.91 D, there were 29 (5.7%), 95 (18.5%), 233 (45.4%) and 156 (30.4%) participants with grade 0 to grade 3 fundus tessellation, respectively. The ChT in both the macular and peripapillary area was negatively correlated with the fundus tessellation grade (R = -0.763 and -0.537, respectively, all p < 0.001). Higher grades of fundus tessellation were independently associated with thinner macular ChT (OR = 1.734, 95% CI: 1.621-1.856, p < 0.001), longer axial length (OR = 1.368, 95% CI: 1.105-1.695, p = 0.004), larger PPA area (OR = 1.391, 95% CI: 1.073-1.802, p = 0.013) and the female sex (OR = 1.605, 95% CI: 1.092-2.359, p = 0.016). Conclusion The fundus tessellation grade could reflect the ChT, representing the severity of myopic maculopathy among young high myopes who rarely had any advanced lesions of pathological myopia. Fundus tessellation grade might be a potential index for assessing early-stage myopic maculopathy in children and adolescents.
引用
收藏
页码:E1524 / E1533
页数:10
相关论文
共 35 条
[1]  
[Anonymous], 1978, Appl. Math. Sci.
[2]   IMPROVEMENTS ON LITTMANN METHOD OF DETERMINING THE SIZE OF RETINAL FEATURES BY FUNDUS PHOTOGRAPHY [J].
BENNETT, AG ;
RUDNICKA, AR ;
EDGAR, DF .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 1994, 232 (06) :361-367
[3]   Morphological Characteristics and Risk Factors of Myopic Maculopathy in an Older High Myopia Population-Based on the New Classification System (ATN) [J].
Chen, Qiuying ;
He, Jiangnan ;
Hu, Guangyi ;
Xu, Xian ;
Lv, Hanyi ;
Yin, Yao ;
Zou, Haidong ;
Zhu, Jianfeng ;
Fan, Ying ;
Xu, Xun .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2019, 208 :356-366
[4]   Impact of the Morphologic Characteristics of Optic Disc on Choroidal Thickness in Young Myopic Patients [J].
Chen, Qiuying ;
He, Jiangnan ;
Yin, Yao ;
Zhou, Hongfeng ;
Jiang, Huifen ;
Zhu, Jianfeng ;
Ohno-Matsui, Kyoko ;
Zou, Haidong ;
Fan, Ying ;
Xu, Xun .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2019, 60 (08) :2958-2967
[5]   Distribution Pattern of Choroidal Thickness at the Posterior Pole in Chinese Children With Myopia [J].
Deng, Junjie ;
Li, Xiaoli ;
Jin, Jiali ;
Zhang, Bo ;
Zhu, Jianfeng ;
Zou, Haidong ;
Xu, Xun ;
Xie, Jingbo ;
Wang, Ling ;
Zhu, Shaopin ;
He, Xiangui .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2018, 59 (03) :1577-1586
[6]   PREVALENCE AND TIME TRENDS OF MYOPIA IN CHILDREN AND ADOLESCENTS IN CHINA A Systemic Review and Meta-Analysis [J].
Dong, Li ;
Kang, Yi Kun ;
Li, Yang ;
Wei, Wen Bin ;
Jonas, Jost B. .
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2020, 40 (03) :399-411
[7]   Progression of Myopic Maculopathy during 18-Year Follow-up [J].
Fang, Yuxin ;
Yokoi, Tae ;
Nagaoka, Natsuko ;
Shinohara, Kosei ;
Onishi, Yuka ;
Ishida, Tomoka ;
Yoshida, Takeshi ;
Xu, Xian ;
Jonas, Jost B. ;
Ohno-Matsui, Kyoko .
OPHTHALMOLOGY, 2018, 125 (06) :863-877
[8]   Prevalence and Associations of Fundus Tessellation Among Junior Students From Greater Beijing [J].
Guo, Yin ;
Liu, Lijuan ;
Zheng, Deqiang ;
Duan, Jiali ;
Wang, Youxin ;
Jonas, Jost B. ;
Tian, Feifei ;
Wang, Shuo ;
Sang, Yujian ;
Zhang, Xiaoyu ;
Cao, Weijie ;
Zhang, Jinxia ;
Sun, Ming ;
Tian, Qiuyue ;
Meng, Xiaoni ;
Guo, Xiuhua ;
Wu, Lijuan .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2019, 60 (12) :4033-4040
[9]   The Complications of Myopia: A Review and Meta-Analysis [J].
Haarman, Annechien E. G. ;
Enthoven, Clair A. ;
Tideman, J. Willem L. ;
Tedja, Milly S. ;
Verhoeven, Virginie J. M. ;
Klaver, Caroline C. W. .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2020, 61 (04)
[10]   Long-term Pattern of Progression of Myopic Maculopathy A Natural History Study [J].
Hayashi, Kengo ;
Ohno-Matsui, Kyoko ;
Shimada, Noriaki ;
Moriyama, Muka ;
Kojima, Ariko ;
Hayashi, Wakako ;
Yasuzumi, Kenjiro ;
Nagaoka, Natsuko ;
Saka, Natsuko ;
Yoshida, Takeshi ;
Tokoro, Takashi ;
Mochizuki, Manabu .
OPHTHALMOLOGY, 2010, 117 (08) :1595-U174