Induction chemotherapy in locally advanced squamous cell carcinoma of the head and neck

被引：18

作者：

Okano, Susumu ^{[1
]}

Homma, Akihiro ^{[2
,3
]}

Kiyota, Naomi ^{[4
]}

Tahara, Makoto ^{[1
]}

Hanai, Nobuhiro ^{[5
]}

Asakage, Takahiro ^{[6
]}

Matsuura, Kazuto ^{[7
]}

Ogawa, Takenori ^{[8
]}

Saito, Yuki ^{[9
]}

Sano, Daisuke ^{[10
]}

Kodaira, Takeshi ^{[11
]}

Motegi, Atsushi ^{[12
]}

Yasuda, Koichi ^{[3
,13
]}

Takahashi, Shunji ^{[14
]}

Tanaka, Kaoru ^{[15
]}

Onoe, Takuma ^{[16
]}

Yokota, Tomoya ^{[17
]}

Imamura, Yoshinori ^{[4
]}

Ariizumi, Yosuke ^{[6
]}

Akimoto, Tetsuo ^{[12
]}

Hayashi, Ryuichi ^{[7
]}

机构：

[1] Natl Canc Ctr Hosp East, Dept Head & Neck Med Oncol, 6-5-1 Kashiwanoha, Kashiwa, Chiba 2778577, Japan

[2] Hokkaido Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, Sapporo, Hokkaido, Japan

[3] Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido, Japan

[4] Kobe Univ Hosp, Canc Ctr, Dept Med Oncol & Hematol, Kobe, Hyogo, Japan

[5] Aichi Canc Ctr Hosp, Dept Head & Neck Surg, Nagoya, Aichi, Japan

[6] Tokyo Med & Dent Univ, Dept Head & Neck Surg, Bunkyo Ku, Tokyo, Japan

[7] Natl Canc Ctr Hosp East, Dept Head & Neck Surg, Kashiwa, Chiba, Japan

[8] Gifu Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Gifu, Gifu, Japan

[9] Univ Tokyo, Dept Otolaryngol & Head & Neck Surg, Bunkyo Ku, Tokyo, Japan

[10] Yokohama City Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Yokohama, Kanagawa, Japan

[11] Aichi Canc Ctr Hosp, Dept Radiat Oncol, Nagoya, Aichi, Japan

[12] Natl Canc Ctr Hosp East, Dept Radiat Oncol, Kashiwa, Chiba, Japan

[13] Hokkaido Univ, Fac Med, Dept Radiat Oncol, Sapporo, Hokkaido, Japan

[14] Canc Inst Hosp, Dept Med Oncol, Tokyo, Japan

[15] Kindai Univ, Dept Med Oncol, Fac Med, Sayama, Osaka, Japan

[16] Hyogo Canc Ctr, Dept Med Oncol, Akashi, Hyogo, Japan

[17] Shizuoka Canc Ctr, Div Gastrointestinal Oncol, Shizuoka, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2021年 / 51卷 / 02期

关键词：

squamous cell carcinoma; head and neck; induction; chemotherapy; organ preservation; PHASE-III TRIAL; CONCURRENT CHEMORADIOTHERAPY; LARYNX PRESERVATION; UNRESECTABLE HEAD; RANDOMIZED-TRIAL; CANCER; CISPLATIN; FLUOROURACIL; DOCETAXEL; RADIATION;

D O I：

10.1093/jjco/hyaa220

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In order to maximize the benefit of induction chemotherapy, practice based on a comprehensive interpretation of a large number of clinical trials, as in this review, is essential. The standard treatment for locally advanced squamous cell carcinoma of the head and neck is surgery or chemoradiation. However, induction chemotherapy followed by (chemo) radiotherapy may be used in some circumstances. Although many clinical trials of induction chemotherapy have been conducted, a rationale other than to preserve the larynx is still controversial. Selection of this modality should therefore be made with care. The current standard regimen for induction chemotherapy is docetaxel, cisplatin and 5-FU, but concerns remain about toxicity, cost and the duration of treatment. Regarding treatment after induction chemotherapy, it is also unclear whether radiation alone or chemoradiation is the better option. Furthermore, there is no answer as to what drugs should be used in combination with radiation therapy after induction chemotherapy. Several new induction chemotherapy treatment developments are currently underway, and future developments are expected. This review article summarizes the current position of induction chemotherapy for head and neck squamous cell carcinoma, based on the evidence produced to date, and discusses the future prospects for this treatment.

引用

页码：173 / 179

页数：7

共 27 条

[1] Intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer [J].

Adelstein, DJ ;

Li, Y ;

Adams, GL ;

Wagner, H ;

Kish, JA ;

Ensley, JF ;

Schuller, DE ;

Forastiere, AA .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (01) :92-98

[2]

[Anonymous], CANC REG STAT

[3] Taxane-Cisplatin-Fluorouracil As Induction Chemotherapy in Locally Advanced Head and Neck Cancers: An Individual Patient Data Meta-Analysis of the Meta-Analysis of Chemotherapy in Head and Neck Cancer Group [J].

Blanchard, Pierre ;

Bourhis, Jean ;

Lacas, Benjamin ;

Posner, Marshall R. ;

Vermorken, Jan B. ;

Cruz Hernandez, Juan J. ;

Bourredjem, Abderrahmane ;

Calais, Gilles ;

Paccagnella, Adriano ;

Hitt, Ricardo ;

Pignon, Jean-Pierre .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (23) :2854-+

[4]

Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]

[5] TPF Sequential Therapy: When and for Whom? [J].

Budach, Volker .

ONCOLOGIST, 2010, 15 :13-18

[6] Phase III Randomized Trial of Induction Chemotherapy in Patients With N2 or N3 Locally Advanced Head and Neck Cancer [J].

Cohen, Ezra E. W. ;

Karrison, Theodore G. ;

Kocherginsky, Masha ;

Mueller, Jeffrey ;

Egan, Robyn ;

Huang, Chao H. ;

Brockstein, Bruce E. ;

Agulnik, Mark B. ;

Mittal, Bharat B. ;

Yunus, Furhan ;

Samant, Sandeep ;

Raez, Luis E. ;

Mehra, Ranee ;

Kumar, Priya ;

Ondrey, Frank ;

Marchand, Patrice ;

Braegas, Bettina ;

Seiwert, Tanguy Y. ;

Villaflor, Victoria M. ;

Haraf, Daniel J. ;

Vokes, Everett E. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (25) :2735-+

[7] A multicenter phase II trial of paclitaxel, carboplatin, and cetuximab followed by chemoradiotherapy in patients with unresectable locally advanced squamous cell carcinoma of the head and neck [J].

Enokida, Tomohiro ;

Ogawa, Takenori ;

Homma, Akihiro ;

Okami, Kenji ;

Minami, Shujiro ;

Nakanome, Ayako ;

Shimizu, Yasushi ;

Maki, Daisuke ;

Ueda, Yuri ;

Fujisawa, Takao ;

Motegi, Atsushi ;

Ohkoshi, Akira ;

Taguchi, Jun ;

Ebisumoto, Koji ;

Nomura, Shogo ;

Okano, Susumu ;

Tahara, Makoto .

CANCER MEDICINE, 2020, 9 (05) :1671-1682

[8] Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer [J].

Forastiere, AA ;

Goepfert, H ;

Maor, M ;

Pajak, TF ;

Weber, R ;

Morrison, W ;

Glisson, B ;

Trotti, A ;

Ridge, JA ;

Chao, C ;

Peters, G ;

Lee, DJ ;

Leaf, A ;

Ensley, J ;

Cooper, J .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (22) :2091-2098

[9] Long-Term Results of RTOG 91-11: A Comparison of Three Nonsurgical Treatment Strategies to Preserve the Larynx in Patients With Locally Advanced Larynx Cancer [J].

Forastiere, Arlene A. ;

Zhang, Qiang ;

Weber, Randal S. ;

Maor, Moshe H. ;

Goepfert, Helmuth ;

Pajak, Thomas F. ;

Morrison, William ;

Glisson, Bonnie ;

Trotti, Andy ;

Ridge, John A. ;

Thorstad, Wade ;

Wagner, Henry ;

Ensley, John F. ;

Cooper, Jay S. .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (07) :845-852

[10] Induction Chemotherapy Followed by Cetuximab Radiotherapy Is Not Superior to Concurrent Chemoradiotherapy for Head and Neck Carcinomas: Results of the GORTEC 2007-02 Phase III Randomized Trial [J].

Geoffrois, Lionnel ;

Martin, Laurent ;

De Raucourt, Dominique ;

Sun, Xu Shan ;

Tao, Yungan ;

Maingon, Philippe ;

Buffet, Joelle ;

Pointreau, Yoann ;

Sire, Christian ;

Tuchais, Claude ;

Babin, Emmanuel ;

Coutte, Alexandre ;

Rolland, Frederic ;

Kaminsky, Marie-Christine ;

Alfonsi, Marc ;

Lapeyre, Michel ;

Saliou, Marie ;

Lafond, Cedric ;

Jadaud, Eric ;

Gery, Bernard ;

Zawadi, Ayman ;

Tourani, Jean-Marc ;

Khoury, Cedric ;

Henry, Anne Rose ;

Hasbini, Ali ;

Guichard, Francois ;

Borel, Christian ;

Meert, Nicolas ;

Guillet, Pierre ;

Calais, Marie-Helene ;

Garaud, Pascal ;

Bourhis, Jean .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (31) :3077-+

← 1 2 3 →