Primary mediastinal large B-cell lymphoma in a patient on Fingolimod for relapsing-remitting multiple sclerosis

被引：5

作者：

Chacko, Joseph A. ^{[1
]}

Strati, Paolo ^{[2
]}

Stout, Paul W. ^{[3
]}

Archer, Robert L. ^{[1
]}

Baltz, Brad P. ^{[4
]}

Chacko, Joseph G. ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Coll Med, Little Rock, AR 72205 USA

[2] Univ Texas MD Anderson Canc Ctr, Div Canc Med, Dept Lymphoma Myeloma, Houston, TX 77030 USA

[3] Arkansas Pathol Associates PA, Little Rock, AR USA

[4] CHI St Vincent Infirm, Hematol Oncol Div, Little Rock, AR USA

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2021年 / 49卷

关键词：

Multiple sclerosis; Fingolimod; Lymphoma; Primary mediastinal large B-cell lymphoma; CD30;

D O I：

10.1016/j.msard.2021.102776

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: There are multiple case reports in the literature describing an association between fingolimod and cutaneous neoplasms. Objective: Investigate and report a case of a primary mediastinal large B-cell lymphoma in a patient on fingolimod for Relapsing-Remitting Multiple Sclerosis (RRMS). Methods: Case Report. Results: The patient developed a primary mediastinal large B-cell lymphoma after seven years of treatment with fingolimod. The patient is currently in complete remission after cessation of treatment, surgical resection, chemotherapy, and radiation therapy. Conclusion: This case report highlights the first primary mediastinal large B-cell lymphoma associated with fingolimod treatment. It should be considered a rare, but potential adverse effect of fingolimod.

引用

页数：3

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