Mutation of epidermal growth factor receptor gene in adenosquamous carcinoma of the lung

被引：37

作者：

Sasaki, Hidefumi ^{[1
]}

Endo, Katsuhiko ^{[1
]}

Yukiue, Haruhiro ^{[1
]}

Kobayashi, Yoshihiro ^{[1
]}

Yano, Motoki ^{[1
]}

Fujii, Yoshitaka ^{[1
]}

机构：

[1] Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

来源：

LUNG CANCER | 2007年 / 55卷 / 01期

关键词：

EGFR; mutation; adenosquamous;

D O I：

10.1016/j.lungcan.2006.09.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have investigated 26 adenosquamous lung cancer tissues and found that four EGFR mutations were mainly in female and non-smoker lung cancer. However, EGFR mutation at kinase domain was exclusive with K-ras mutation. However, smoking and gender status could affect the occurrence of EGFR mutation. There was no difference in EGFR mutation status if analysis was performed in never smoker female subgroup. (c) 2006 Elsevier Ireland Ltd. AR rights reserved.

引用

页码：129 / 130

页数：2

共 16 条

[1] Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay [J].

Endo, K ;

Konishi, A ;

Sasaki, H ;

Takada, M ;

Tanaka, H ;

Okumura, M ;

Kawahara, M ;

Sugiura, H ;

Kuwabara, Y ;

Fukai, I ;

Matsumura, A ;

Yano, M ;

Kobayashi, Y ;

Mizuno, K ;

Haneda, H ;

Suzuki, E ;

Iuchi, K ;

Fujii, Y .

LUNG CANCER, 2005, 50 (03) :375-384

[2] Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer [J].

Graziano, SL ;

Gamble, GP ;

Newman, NB ;

Abbott, LZ ;

Rooney, M ;

Mookherjee, S ;

Lamb, ML ;

Kohman, LJ ;

Poiesz, BJ .

JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (02) :668-675

[3] Epidermal growth factor receptor gene mutation defines distinct subsets among small adenocarcinomas of the lung [J].

Haneda, H ;

Sasaki, H ;

Shimizu, S ;

Endo, K ;

Suzuki, E ;

Yukiue, H ;

Kobayashi, Y ;

Yano, M ;

Fujii, Y .

LUNG CANCER, 2006, 52 (01) :47-52

[4] Transition from squamous cell carcinoma to adenocarcinoma in adenosquamous carcinoma of the lung [J].

Kanazawa, H ;

Ebina, M ;

Ino-oka, N ;

Shimizukawa, M ;

Takahashi, T ;

Fujimura, S ;

Imai, T ;

Nukiwa, T .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (04) :1289-1298

[5] Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib [J].

Lynch, TJ ;

Bell, DW ;

Sordella, R ;

Gurubhagavatula, S ;

Okimoto, RA ;

Brannigan, BW ;

Harris, PL ;

Haserlat, SM ;

Supko, JG ;

Haluska, FG ;

Louis, DN ;

Christiani, DC ;

Settleman, J ;

Haber, DA .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (21) :2129-2139

[6] Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence [J].

Mitsudomi, T ;

Kosaka, T ;

Endoh, H ;

Horio, Y ;

Hida, T ;

Mori, S ;

Hatooka, S ;

Shinoda, M ;

Takahashi, T ;

Yatabe, Y .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (11) :2513-2520

[7] ADENOSQUAMOUS LUNG-CARCINOMA - CLINICAL CHARACTERISTICS, TREATMENT, AND PROGNOSIS [J].

NAUNHEIM, KS ;

TAYLOR, JR ;

SKOSEY, C ;

HOFFMAN, PC ;

FERGUSON, MK ;

GOLOMB, HM ;

LITTLE, AG .

ANNALS OF THORACIC SURGERY, 1987, 44 (05) :462-466

[8] Clonal analysis of adenosquamous carcinoma of the lung [J].

Niho, S ;

Yokose, T ;

Kodama, T ;

Nishiwaki, Y ;

Mukai, K .

JAPANESE JOURNAL OF CANCER RESEARCH, 1999, 90 (11) :1244-1247

[9] EGFR mutations in lung cancer:: Correlation with clinical response to gefitinib therapy [J].

Paez, JG ;

Jänne, PA ;

Lee, JC ;

Tracy, S ;

Greulich, H ;

Gabriel, S ;

Herman, P ;

Kaye, FJ ;

Lindeman, N ;

Boggon, TJ ;

Naoki, K ;

Sasaki, H ;

Fujii, Y ;

Eck, MJ ;

Sellers, WR ;

Johnson, BE ;

Meyerson, M .

SCIENCE, 2004, 304 (5676) :1497-1500

[10] EGFR mutation status and prognosis for gefitinib treatment in Japanese lung cancer [J].

Sasaki, H ;

Endo, K ;

Mizuno, K ;

Yano, M ;

Fukai, I ;

Yamakawa, Y ;

Fujii, Y .

LUNG CANCER, 2006, 51 (01) :135-136

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