A novel catalytic system for the Mannich-type reaction of silyl enolates:: Stereoselective synthesis of β-aminoketones

被引：0
|
作者：
Miura, K
Tamaki, K
Nakagawa, T
Hosomi, A [1 ]
机构：
[1] Univ Tsukuba, Dept Chem, Tsukuba, Ibaraki 3058571, Japan
[2] Univ Tsukuba, Grad Sch Chem, Tsukuba, Ibaraki 3058571, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2000年 / 39卷 / 11期
关键词：
D O I：
10.1002/1521-3773(20000602)39:11<1958::AID-ANIE1958>3.0.CO;2-4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Water and a catalytic amount of iPr2NH effectively induces the Mannich- type reaction of ketone dimethylsilyl enolates with aromatic and α,β- unsaturated N-sulfonylimines, to afford β-aminoketones in good to excellent yields with high levels of anti selectivity [Eq. (1)].
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页码：1958 / +
页数：4
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