Clinical practice recommendations for growth hormone treatment in children with chronic kidney disease

被引：108

作者：

Drube, Jens ^{[1
,2
]}

Wan, Mandy ^{[3
]}

Bonthuis, Marjolein ^{[4
]}

Wuhl, Elke ^{[5
]}

Bacchetta, Justine ^{[6
]}

Santos, Fernando ^{[7
]}

Grenda, Ryszard ^{[8
]}

Edefonti, Alberto ^{[9
]}

Harambat, Jerome ^{[4
,10
]}

Shroff, Rukshana ^{[3
]}

Tonshoff, Burkhard ^{[5
]}

Haffner, Dieter ^{[1
,2
]}

Schnabel, D. ^{[11
]}

Linglart, A. ^{[12
]}

Rees, L. ^{[13
]}

Cochat, P. ^{[14
]}

Brauner, C. ^{[15
]}

Renault, D. ^{[16
]}

Romano, L. N. ^{[17
]}

Colling, G. ^{[18
]}

Prytula, A. ^{[19
]}

Leifheit-Nestler, M. ^{[20
]}

Klaus, G. ^{[21
,41
]}

Schmitt, C. P. ^{[22
,40
]}

Stabouli, S. ^{[23
,43
]}

Reusz, G. ^{[24
]}

Verrina, E. ^{[25
,45
]}

Groothoff, J. ^{[26
]}

Anton-Gamero, M. ^{[27
]}

Petrosyan, E. ^{[28
,65
]}

Bakkaloglu, S. A. ^{[29
]}

Dursun, I. ^{[30
]}

Booth, C. ^{[31
]}

Aufricht, C. ^{[32
]}

Vande Walle, J. ^{[33
]}

Vondrak, K. ^{[34
]}

Holtta, T. ^{[35
,36
]}

Ranchin, B. ^{[37
,38
]}

Fischbach, M. ^{[39
]}

Schmitt, C. P. ^{[22
,40
]}

Klaus, G. ^{[21
,41
]}

Stefanidis, C. ^{[42
]}

Kyriakou, A. ^{[42
]}

Stabouli, S. ^{[23
,43
]}

Printza, N. ^{[43
]}

Paglialonga, F. ^{[44
]}

Verrina, E. ^{[25
,45
]}

Vidal, E. ^{[46
]}

Allinovi, M. ^{[47
]}

Jankauskiene, A. ^{[48
]}

机构：

[1] Hannover Med Sch, Childrens Hosp, Dept Pediat Kidney Liver & Metab Dis, Hannover, Germany

[2] Hannover Med Sch, Ctr Rare Dis, Ctr Congenital Kidney Dis, Hannover, Germany

[3] Great Ormond St Hosp Sick Children, Renal Unit, London, England

[4] Univ Amsterdam, Acad Med Ctr, Dept Med Informat, ESPN ERA EDTA Registry, Amsterdam, Netherlands

[5] Univ Childrens Hosp, Dept Pediat 1, Heidelberg, Germany

[6] Univ Childrens Hosp, Dept Pediat Nephrol Rheumatol & Dermatol, Lyon, France

[7] SESPA, Hlth Serv Principal Asturias, Hosp Univ Cent Asturias HUCA, Dept Pediat, Oviedo, Spain

[8] Childrens Mem Hlth Inst, Kidney Transplantat & Arterial Hypertens, Dept Nephrol, Warsaw, Poland

[9] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy

[10] Bordeaux Univ Hosp, Pediat Nephrol Unit, Dept Pediat, Bordeaux, France

[11] Charite Univ Med Berlin, Berlin, Germany

[12] Bicetre Paris Sud Hosp, APHP, Endocrinol & Diabet Children, Le Kremlin Bicetre, France

[13] Great Ormond St Hosp Sick Children, Renal Unit, London, England

[14] Univ Childrens Hosp, Dept Paediat Nephrol Rheumatol & Dermatol, Lyon, France

[15] Patient Org Children CKD Lower Saxony, Hannover, Germany

[16] Federat European Associat Patients Affected Genet, Villers La Ville, Belgium

[17] La Nuova Speranza Lotta Glomerulosclerosi ONLUS, Milan, Italy

[18] Great Ormond St Hosp Sick Children, Paediat Renal Patient Org, London, England

[19] Univ Ghent, Ghent, Belgium

[20] Hannover Med Sch, Hannover, Germany

[21] Univ Childrens Hosp, Marburg, Germany

[22] Heidelberg Univ, Heidelberg, Germany

[23] Aristotle Univ Thessaloniki, Thessaloniki, Greece

[24] Semmelweis Univ, Budapest, Hungary

[25] G Gaslini Inst Children, Genoa, Italy

[26] Acad Med Ctr, Amsterdam, Netherlands

[27] Reina Sofia Univ Hosp, Cordoba, Spain

[28] Russian Natl Res Med Univ, Moscow, Russia

[29] Gazi Univ Hosp, Ankara, Turkey

[30] Erciyes Univ, Fac Med, Kayseri, Turkey

[31] Evelina London Guys & St Thomas, London, England

[32] Med Univ Vienna, Vienna, Austria

[33] Univ Hosp Ghent, Ghent, Belgium

[34] Charles Univ Prague, Univ Hosp Motol, Prague, Czech Republic

[35] Univ Helsinki, Helsinki, Finland

[36] Helsinki Univ Hosp, Helsinki, Finland

[37] Hosp Civils Lyon, Ctr Reference Malad Renales Hereditaires, Lyon, France

[38] Univ Lyon, Lyon, France

[39] Hautepierre Univ Hosp, Strasbourg, France

[40] Heidelberg Univ, Heidelberg, Germany

[41] Univ Childrens Hosp, Marburg, Germany

[42] Childrens Hosp, Athens, Greece

[43] Aristotle Univ Thessaloniki, Thessaloniki, Greece

[44] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy

[45] Giannina Gaslini Childrens Hosp, Genoa, Italy

[46] Univ Hosp Padova, Padua, Italy

[47] Univ Florence, Dept Biomed Expt & Clin Sci, Florence, Italy

[48] Vilnius Univ, Children Hosp, Vilnius, Lithuania

[49] Med Univ Gdansk, Gdansk, Poland

[50] Hosp Maria Pia, Porto, Portugal

来源：

NATURE REVIEWS NEPHROLOGY | 2019年 / 15卷 / 09期

基金：

美国国家卫生研究院;

关键词：

CHRONIC-RENAL-FAILURE; LONG-TERM GROWTH; DOUBLE-BLIND TRIAL; QUALITY-OF-LIFE; CATCH-UP GROWTH; PREPUBERTAL CHILDREN; ADULT HEIGHT; SHORT STATURE; REPLACEMENT THERAPY; PEDIATRIC-PATIENTS;

D O I：

10.1038/s41581-019-0161-4

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Achieving normal growth is one of the most challenging problems in the management of children with chronic kidney disease (CKD). Treatment with recombinant human growth hormone (GH) promotes longitudinal growth and likely enables children with CKD and short stature to reach normal adult height. Here, members of the European Society for Paediatric Nephrology (ESPN) CKD-Mineral and Bone Disorder (MBD), Dialysis and Transplantation working groups present clinical practice recommendations for the use of GH in children with CKD on dialysis and after renal transplantation. These recommendations have been developed with input from an external advisory group of paediatric endocrinologists, paediatric nephrologists and patient representatives. We recommend that children with stage 3-5 CKD or on dialysis should be candidates for GH therapy if they have persistent growth failure, defined as a height below the third percentile for age and sex and a height velocity below the twenty-fifth percentile, once other potentially treatable risk factors for growth failure have been adequately addressed and provided the child has growth potential. In children who have received a kidney transplant and fulfil the above growth criteria, we recommend initiation of GH therapy 1 year after transplantation if spontaneous catch-up growth does not occur and steroid-free immunosuppression is not a feasible option. GH should be given at dosages of 0.045-0.05 mg/kg per day by daily subcutaneous injections until the patient has reached their final height or until renal transplantation. In addition to providing treatment recommendations, a cost-effectiveness analysis is provided that might help guide decision-making.

引用

页码：577 / 589

页数：13

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