Adsorption and controlled release of Chlortetracycline HCl by using multifunctional polymeric hydrogels

被引：22

作者：

Abou Taleb, Manal F. ^{[1
]}

Abdel-Aal, Samia E. ^{[1
]}

El-Kelesh, Nabil A. ^{[1
]}

Hegazy, El-Sayed A. ^{[1
]}

机构：

[1] Natl Ctr Radiat Res & Technol, Cairo, Egypt

来源：

EUROPEAN POLYMER JOURNAL | 2007年 / 43卷 / 02期

关键词：

Chlortetracycline HCl; methacrylic acid; hydrogel; radiation; drug release;

D O I：

10.1016/j.eurpolymj.2006.11.001

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Adsorption and controlled release of Chlortetracycline HCl to and from multifunctional polymeric materials (HEMA/MAA) hydrogels were investigated. P(HEMA/MAA) hydrogels were synthesized by gamma radiation-induced copolymerization of 2-hydroxyethylmethacrylate (HEMA) and methacrylic acid (MAA) in aqueous solution. The influence of copolymer composition and pH value of the surrounding medium on the type of water diffusion into the glassy polymer were discussed. Drug, Chlortetracycline HCl containing hydrogels, with different drug concentration to polymer ratios, was loaded by direct adsorption method. The influence of MAA content in the gel on the adsorption capacities of hydrogel was studied. Chlortetracycline HCl adsorption capacity of hydrogels was found to increase from 8 to 138 mg Chlortetracycline HCl per gram dry gel with increasing amount of MAA in the gel system and drug concentration. The effect of pH on the releasing behavior of Chlortetracycline HCl from gel matrix was investigated. In vitro drug release studies in different buffer solutions show that the basic parameters affecting the drug release behavior of hydrogel are the pH of the solution and MAA content of hydrogel. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：468 / 477

页数：10

共 22 条

[1] Synthesis and characterization of PVP/AAc copolymer hydrogel and its applications in the removal of heavy metals from aqueous solution [J].