The modular phosphorylation and activation of p70(s6k)

被引：488
作者：
Pullen, N [1 ]
Thomas, G [1 ]
机构：
[1] FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND
来源：
FEBS LETTERS | 1997年 / 410卷 / 01期
关键词：
modular phosphorylation; p70(s6k);
D O I：
10.1016/S0014-5793(97)00323-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The activation of p70(s6k) is accompanied by a complex series of phosphorylation events. In this review we propose a model of activation which divides p70(s6k) into four functional modules that cooperate in leading to full enzyme activity. In the light of the model, we suggest how candidate effectors of p70(s6k) activation might function by directing the phosphorylation of specific sites. (C) 1997 Federation of European Biochemical Societies.
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收藏
页码：78 / 82
页数：5
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