Efficient Propargylation of Aldehydes and Ketones Catalyzed by Titanocene(III)

被引：53

作者：

Justicia, Jose ^{[1
]}

Sancho-Sanz, Iris ^{[1
]}

Alvarez-Manzaneda, Enrique ^{[1
]}

Enrique Oltra, J. ^{[1
]}

Cuerva, Juan M. ^{[1
]}

机构：

[1] Univ Granada, Dept Organ Chem, Fac Sci, E-18071 Granada, Spain

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 14-15期

关键词：

homogeneous catalysis; propargylation; synthetic methods; titanium; EPOXYPOLYENE CYCLIZATION; STRAIGHTFORWARD SYNTHESIS; ORGANIC-SYNTHESIS; ALLENIC ALCOHOLS; TI-III; RADICALS; ADDITIONS; TERPENOIDS; REAGENTS; EPOXIDES;

D O I：

10.1002/adsc.200900479

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We describe a novel method for the propargylation of a wide range of aldehydes and ketones catalyzed by titanocene(III) complexes under mild reaction conditions and compatible with many functional groups. Homopropargylic alcohols are obtained as the sole products even when ketones are used as starting materials, which is unusual in Barbier-type propargylations.

引用

页码：2295 / 2300

页数：6

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