Of Older Mice and Men: Branched-Chain Amino Acids and Body Composition

被引：20

作者：

Ribeiro, Rosilene, V ^{[1
,2
]}

Solon-Biet, Samantha M. ^{[1
,2
,3
]}

Pulpitel, Tamara ^{[1
,2
]}

Senior, Alistair M. ^{[1
,2
]}

Cogger, Victoria C. ^{[2
,3
]}

Clark, Ximonie ^{[1
,2
]}

O'Sullivan, John ^{[2
,4
]}

Koay, Yen Chin ^{[2
,4
]}

Hirani, Vasant ^{[1
,2
,5
]}

Blyth, Fiona M. ^{[6
]}

Seibel, Markus J. ^{[3
,6
,7
]}

Waite, Louise M. ^{[5
]}

Naganathan, Vasi ^{[6
]}

Cumming, Robert G. ^{[5
,8
]}

Handelsman, David J. ^{[7
]}

Simpson, Stephen J. ^{[1
,2
]}

Le Couteur, David G. ^{[1
,2
,3
,9
]}

机构：

[1] Univ Sydney, Fac Sci, Sch Life & Environm Sci, Sydney, NSW 2006, Australia

[2] Univ Sydney, Charles Perkins Ctr, Sydney, NSW 2006, Australia

[3] Univ Sydney, Fac Hlth & Med, Sydney Med Sch, Sydney, NSW 2006, Australia

[4] Univ Sydney, Heart Res Inst, Sydney, NSW 2006, Australia

[5] ARC Ctr Excellence Populat Ageing Res CEPAR, Kensington, NSW 2033, Australia

[6] Univ Sydney, Fac Hlth & Med, Concord Clin Sch, Concord 2139, Australia

[7] Univ Sydney, ANZAC Res Inst, Concord 2139, Australia

[8] Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia

[9] Univ Sydney, Concord Hosp, Ageing & Alzheimers Inst, Concord 2139, Australia

来源：

NUTRIENTS | 2019年 / 11卷 / 08期

基金：

英国医学研究理事会;

关键词：

branched-chain amino acids; body composition; ageing; mice; humans; CONCORD HEALTH; DECREASED CONSUMPTION; INSULIN-RESISTANCE; PROTEIN; AUSTRALIA; PROFILE; RISK;

D O I：

10.3390/nu11081882

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Protein and branched-chain amino acid (BCAA) intake are associated with changes in circulating BCAAs and influence metabolic health in humans and rodents. However, the relationship between BCAAs and body composition in both species is unclear, with many studies questioning the translatability of preclinical findings to humans. Here, we assessed and directly compared the relationship between circulating BCAAs, body composition, and intake in older mice and men. Body weight and body fat were positively associated with circulating BCAA levels in both mouse and human, which remained significant after adjustments for age, physical activity, number of morbidities, smoking status, and source of income in the human cohort. Macronutrient intakes were similarly associated with circulating BCAA levels; however, the relationship between protein intake and BCAAs were more pronounced in the mice. These findings indicate that the relationship between circulating BCAAs, body composition, and intakes are comparable in both species, suggesting that the mouse is an effective model for examining the effects of BCAAs on body composition in older humans.

引用

页数：11

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