Marginal Regression Analysis for Semi-Competing Risks Data Under Dependent Censoring

被引:20
作者
Ding, A. Adam [1 ]
Shi, Guangkai [1 ]
Wang, Weijing [2 ]
Hsieh, Jin-Jian [3 ]
机构
[1] Northeastern Univ, Dept Math, Boston, MA 02115 USA
[2] Natl Chiao Tung Univ, Inst Stat, Hsinchu, Taiwan
[3] Natl Chung Cheng Univ, Dept Math, Taipei, Taiwan
关键词
artificial censoring; log-rank statistic; multiple events data; transformation model; MODEL; RESIDUALS; CHECKING;
D O I
10.1111/j.1467-9469.2008.00635.x
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
Multiple events data are commonly seen in medical applications. There are two types of events, namely terminal and non-terminal. Statistical analysis for non-terminal events is complicated due to dependent censoring. Consequently, joint modelling and inference are often needed to avoid the problem of non-identifiability. This article considers regression analysis for multiple events data with major interest in a non-terminal event such as disease progression. We generalize the technique of artificial censoring, which is a popular way to handle dependent censoring, under flexible model assumptions on the two types of events. The proposed method is applied to analyse a data set of bone marrow transplantation.
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页码:481 / 500
页数:20
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