Efficient whole-cell biotransformation in a biphasic ionic liquid/water system

被引：138

作者：

Pfruender, H

Amidjojo, M

Kragl, U

Weuster-Botz, D

机构：

[1] Tech Univ Munich, Inst Biochem Engn, D-85748 Garching, Germany

[2] Univ Rostock, Dept Chem, D-18059 Rostock, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 34期

关键词：

asymmetric catalysis; biotransformations; cofactors; ionic liquids; whole-cell methods;

D O I：

10.1002/anie.200460241

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biocompatible ionic liquids act as a substrate reservoir and an in situ extracting agent in biotransformations with whole cells (see scheme). In the reduction of 4-chloroacetophenone to (R)-1-(4-chlorophenyl)ethanol, high product concentration (82 g L-1) and purity (99.6% ee) were achieved without the addition of cofactors and without damaging the biocatalyst.

引用

页码：4529 / 4531

页数：3

共 34 条

[1]

[Anonymous], ANGEW CHEM

[2] Novel developments in biocatalytic organic chemistry [J].