Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development

被引：73

作者：

Casas, Rosa ^{[1
,2
]}

Urpi-Sarda, Mireia ^{[3
]}

Sacanella, Emilio ^{[1
,2
]}

Arranz, Sara ^{[1
,2
]}

Corella, Dolores ^{[2
,4
,5
]}

Castaner, Olga ^{[2
,6
]}

Lamuela-Raventos, Rosa-Maria ^{[2
,3
]}

Salas-Salvado, Jordi ^{[2
,7
]}

Lapetra, Jose ^{[2
,8
]}

Portillo, Maria P. ^{[2
,9
]}

Estruch, Ramon ^{[1
,2
]}

机构：

[1] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Villarroel 170, E-08036 Barcelona, Spain

[2] Inst Salud Carlos III, Ciber Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain

[3] Univ Barcelona, Sch Pharm, Dept Nutr & Food Sci, Av Joan XXIII S-N, E-08028 Barcelona, Spain

[4] Univ Valencia, Sch Med, Dept Epidemiol, Valencia, Spain

[5] Univ Valencia, Sch Med, Dept Biochem & Mol Biol, Valencia, Spain

[6] Hosp Mar Med Res Inst IMIM, Cardiovasc Risk & Nutr & REGICOR Res Grp, Barcelona, Spain

[7] Univ Rovira & Virgili, Hosp Univ Sant Joan Reus, IISPV, Human Nutr Unit, Reus, Spain

[8] Distrito Sanitario Atenc Primaria Sevilla, Dept Family Med, Res Unit, Seville, Spain

[9] Univ Basque Country, UPV EHU, Lucio Lascaray Res Ctr, Dept Nutr & Food Sci,Nutr & Obes Grp, Vitoria, Spain

来源：

MEDIATORS OF INFLAMMATION | 2017年 / 2017卷

关键词：

LOW-GRADE INFLAMMATION; CARDIOVASCULAR-DISEASE; HIGH-RISK; MARKERS; ATHEROSCLEROSIS; ACTIVATION; CYTOKINES; PATTERN;

D O I：

10.1155/2017/3674390

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Objective. To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex (R). Results. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1 beta (P < 0.05; all) compared to LFD. IL-1 beta, IL-5, IL-7, IL-12p70, IL-18, TNF-alpha, IFN-gamma, GCSF, GMCSF, and ENA78 (P < 0 05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P < 0 05; both) in the MeDiet+nuts group. Conclusions. Long-term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.

引用

页数：12

共 30 条

[21] Antioxidants, inflammation and cardiovascular disease [J].