Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development

被引:72
作者
Casas, Rosa [1 ,2 ]
Urpi-Sarda, Mireia [3 ]
Sacanella, Emilio [1 ,2 ]
Arranz, Sara [1 ,2 ]
Corella, Dolores [2 ,4 ,5 ]
Castaner, Olga [2 ,6 ]
Lamuela-Raventos, Rosa-Maria [2 ,3 ]
Salas-Salvado, Jordi [2 ,7 ]
Lapetra, Jose [2 ,8 ]
Portillo, Maria P. [2 ,9 ]
Estruch, Ramon [1 ,2 ]
机构
[1] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Villarroel 170, E-08036 Barcelona, Spain
[2] Inst Salud Carlos III, Ciber Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain
[3] Univ Barcelona, Sch Pharm, Dept Nutr & Food Sci, Av Joan XXIII S-N, E-08028 Barcelona, Spain
[4] Univ Valencia, Sch Med, Dept Epidemiol, Valencia, Spain
[5] Univ Valencia, Sch Med, Dept Biochem & Mol Biol, Valencia, Spain
[6] Hosp Mar Med Res Inst IMIM, Cardiovasc Risk & Nutr & REGICOR Res Grp, Barcelona, Spain
[7] Univ Rovira & Virgili, Hosp Univ Sant Joan Reus, IISPV, Human Nutr Unit, Reus, Spain
[8] Distrito Sanitario Atenc Primaria Sevilla, Dept Family Med, Res Unit, Seville, Spain
[9] Univ Basque Country, UPV EHU, Lucio Lascaray Res Ctr, Dept Nutr & Food Sci,Nutr & Obes Grp, Vitoria, Spain
关键词
LOW-GRADE INFLAMMATION; CARDIOVASCULAR-DISEASE; HIGH-RISK; MARKERS; ATHEROSCLEROSIS; ACTIVATION; CYTOKINES; PATTERN;
D O I
10.1155/2017/3674390
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Objective. To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex (R). Results. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1 beta (P < 0.05; all) compared to LFD. IL-1 beta, IL-5, IL-7, IL-12p70, IL-18, TNF-alpha, IFN-gamma, GCSF, GMCSF, and ENA78 (P < 0 05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P < 0 05; both) in the MeDiet+nuts group. Conclusions. Long-term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.
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页数:12
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